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10 articles found
Adenocarcinoma of the breast represents a significant subset of breast cancers, characterized by the malignancy of glandular tissues. This specific article focuses on the right medial segment, highlighting its histopathological features, diagnostic methods, and potential therapeutic avenues. Overview of Adenocarcinoma Adenocarcinomas in the breast typically arise from the epithelial cells lining ...
Lipids, often simply thought of as fats, play a far more complex and vital role in our bodies than just energy storage. They are fundamental building blocks for cell membranes, crucial for nutrient absorption, and, significantly, the precursors to a powerful class of signaling molecules: steroid hormones. Understanding the deep connection between Lipid Metabolism and these hormones, along with ...
Breast cancer is a type of cancer that begins in the cells of the breast. It can occur in both men and women but is more common in women. Breast cancer can develop in different parts of the breast, including the tubes that carry milk to the nipple or the lobules that produce milk. The exact cause of breast cancer is not completely understood, but factors such as genetics, hormone situations, ...
Introduction of Drug Affinity Responsive Target Stability (DARTS) Drug target protein identification is an important step in the research and development of new drugs. Drug Affinity Response Target Stability (DARTS) is a technique that can rapidly and directly identify potential target proteins of small molecule drugs. That is, it prevents the target protein from being hydrolyzed by proteases ...
When you hear about the vaginal microbiome (VMB), your first thought may be the role it plays in stuff like yeast infections or bacterial vaginosis (BV). But with improved research, we’re uncovering more of the VMB’s long-term effects, like its role in a healthy pregnancy and delivery. The complex community of organisms living in your vagina even plays a part in your risk of ...
ByJuno Bio
The digital pathology software company PathPresenter (Montville, New Jersey) and the precision oncology platform firm 4D Path have entered into a partnership that could improve the diagnostic accuracy of breast tumor profiling. PathPresenter has developed a digital workflow tool for clinicians, pathologists and pharma companies to aggregate medical data. ...
Abstract This study describes the development of a bioassay to detect the presence of progesterone and progesterone-like molecules in wastewater samples. The basis of the bioassay is the integration of the human progesterone receptor gene into the yeast Arxula adeninivorans for the constitutive synthesis of the receptor. After incubation, binding of the analyte to the receptor induces the ...
As knowledge of contaminants capable of adversely modulating endocrine functions increases, attention is focused on the effects of synthetic progestins as environmental endocrine disrupters. In the present study, effects of exposure to a synthetic progestin (norethindrone, 168 ± 7.5 ng/L) and endogenous progestogen (progesterone, 34 ± 4.1 ng/L) on steroidogenesis in adult female fathead minnows ...
Changes in the endocrine potency of municipal wastewater at 3 wastewater treatment plants (WWTPs) in Australia were investigated using a panel of in vitro receptor‐driven transactivation assays. The assays were based on human estrogen receptor α, androgen receptor, progesterone receptor, glucocorticoid receptor, and peroxisome proliferator‐activated receptor γ2. Total removal efficiencies for ...
Pharmaceuticals and personal care products (PPCPs) have been detected widely in aquatic ecosystems, but little is known about their mechanisms of toxicity. We exposed adult fathead minnows (Pimephales promelas) for 48 hours to triclocarban (1.4 µg/L), DEET (0.6 µg/L) or to a PPCP mixture consisting of atenolol (1.5 µg/L), caffeine (0.25 µg/L), diphenhydramine (0.1 µg/L), gemfibrozil ...