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Disease Lung Articles & Analysis
26 articles found
Idiopathic pulmonary fibrosis (IPF) remains a challenging respiratory disease characterized by progressive lung scarring, with current therapies only slowing disease progression. A 2026 study of human and animal models identifies concurrent inhibition of the transcription regulators ID1 and ID3 as a potential therapeutic approach, given their upregulation in fibroblasts from diseased tissue.Dual ...
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While ...
Research in the field of pulmonary biology often requires detailed analysis of lung tissues. One of the optimal methods for studying lung structures and functions in mice is the use of C57 mouse models, specifically through the preparation of frozen sections. This technique is vital for a variety of applications, including histological studies, immunohistochemistry, and molecular analysis. Why ...
National No Smoking Day is observed in the UK annually on the second Wednesday of March, falling on the 12th of March 2025. Inaugurated on Ash Wednesday in 1984, the day aims to raise awareness of the dangers of smoking and encourage smokers to quit, highlighting the benefits of a smoke-free life. Smoking poses serious health risks, affecting nearly every organ in the body. Smokers significantly ...
Precision-Cut Lung Slices (PCLS) have emerged as a innovative ex vivo model that allows researchers to explore deep into lung physiology, disease mechanisms, and pharmacological responses. By offering a unique combination of biological complexity and controlled experimental conditions, PCLS serve as a critical bridge between the limitations of traditional in vitro cell cultures and the ...
The research goals of Carole Ober’s laboratory at the University of Chicago are to identify genetic variants that influence gene expression and epigenetic patterns in tissues relevant to complex phenotypes, especially related to asthma and fertility. The lab uses both freshly isolated cells, as well as tissue and cell culture models of gene-environment interactions to explore ...
Infants with gas trapping are difficult to manage with conventional ventilation (CMV). HFJV has been used successfully in infants with severe gas trapping. The techniques used during HFJV in this situation are often described as a "low volume strategy". However, there is little published data to indicate optimal ventilator settings, both Jet and conventional, to achieve these aims. During HFJV ...
Discovery In the late 19th century, researchers attempted to produce a drug with a hemostatic effect by injecting a peptone and inducing the release of an anticoagulant. The water-soluble substance isolated from the liver was heparin, but no one knew it at the time. What unfolded over the next four decades would change the trajectory of anticoagulation treatment. By 1915, the most prominent ...
KoKo, LLC announces a partnership for access to Galen Data’s cloud platform. This new partnership provides KoKo direct and secure connectivity to a compliant cloud infrastructure, allowing access virtually anywhere. The secured data can be made accessible to providers and patients. By harnessing this information, KoKo will be able to develop innovative respiratory health solutions that ...
ByKoKo PFT
Obesity rates have been increasing worldwide, especially in North America. Over the past few years, obesity rates have increased to the point that it costs around $14 billion in health expenses each year. The consequences of childhood obesity are numerous, but many wonder about the connection between obesity and asthma. Does childhood obesity make asthma worse? Or is it the other way ...
ByAluna
Patients with asthma should be able to enjoy their busy lives without constant, debilitating symptoms. If you or your child has chronic asthma, make sure you are in control of your asthma. Learn about the risk factors, symptoms, and best practices for controlling your asthma. Identify And Avoid Asthma Triggers Asthma doesn’t “flare-up.” Coughing and wheezing ...
ByAluna
Mayday, mayday, mayday! A flare may be on the horizon, and it could be triggered by your body’s changing levels of condition-based asthma triggers. Even if the early warning signs of an asthma attack aren’t obvious, you can take specific measures to help prevent a flare from happening. This could save your lungs and your life. If a child has asthma, it is crucial for you ...
ByAluna
The Aluna spirometer is an effective tool for remote patient monitoring (RPM). There are many ways that you can use Aluna to better treat asthma patients. Aside from being a quality product, Aluna has an app that makes recording spirometry results fun for children and beneficial for physicians. Here are some ways you can use Aluna to better treat patients who have asthma. The Use Of ...
ByAluna
Some doctors and healthcare professionals refer to “silent asthma,” but you’ve probably had difficulty pinpointing its definition. While this term has made its way into medical practice jargon, it is not generally regarded as a medical term. There are a few reasons why people refer to “silent asthma.” To understand their meaning, you need to know about ...
ByAluna
At Recursion, we are working to decode biology and industrialize drug discovery. We have successfully executed over 82 million phenomic experiments and inferred over 179 billion biological relationships in our quest to identify promising novel therapeutic approaches. Now, we are extending our industrialized approach to petabytes of pre-clinical in vivo studies. Digitalizing in vivo studies ...
Asthma is a health condition that causes a person’s airways to close up, making it difficult to breathe. Around 25 million Americans suffer from asthma, but few fully understand the short and long-term effects of asthma. Understanding how asthma impacts your health is one of the first steps towards managing it and living your life relatively uninhibited. Therefore it’s ...
ByAluna
Asthma can be a difficult illness to manage without a proper diagnosis and treatment plan. This is because there are several types of asthma, each with its own unique triggers. If you or a loved one suffers from asthma, you’re probably aware of common triggers such as exercise, weather, etc. However, one of the hardest types of asthma to identify is allergic asthma. You’ve ...
ByAluna
If you or your child suffers from asthma, you’ve probably heard the term, “pediatric asthma”. However, understanding exactly what pediatric asthma is and how it affects your child is critical in managing their asthma. Furthermore, you may be wondering, does pediatric asthma only apply to children? Perhaps you’re even wondering if your child will outgrow pediatric ...
ByAluna
The Non-Intrusive LuCED Test for Detection of Early-Stage Lung Cancer: A Subgroup Analysis for Chronic Obstructive Pulmonary Disease (COPD) Introduction VisionGate’s LuCED® test for lung cancer measures 934 features in each cell imaged in 3D by the Cell- CT™. Sensitivity and specificity, both exceeding 90%, have been reported (Wilbur, et. al., Cancer Cytopathology, ...
PE is the most common preventable cause of death among hospital patients in the United States. VTE is a leading cause of death and disability worldwide and has the third-highest mortality rate out of any cardiovascular disease, behind myocardial infarctions and stroke. Unlike myocardial infractions and stroke, where mortality has improved considerably, VTE has seen an increase in cases, with no ...