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Autoimmune Disease Articles & Analysis
81 articles found
In June 2025, Capstan Therapeutics announced the initiation of a Phase I clinical trial for CPTX2309, an in vivo CAR-T candidate targeting B-cell–mediated autoimmune diseases. The therapy uses targeted lipid nanoparticles (tLNPs) to deliver CAR-encoding mRNA directly to immune cells. ...
Blocking CCR1 can blunt harmful inflammation but risks impairing protective immunity. Clinical Relevance: From Autoimmunity to Oncology In autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease, CCR1 signaling sustains leukocyte infiltration into tissues. Elevated CCR1 expression ...
Investigating the thymus of rats provides valuable insights into immunological processes and disease mechanisms. One of the most effective methods for preserving and studying the cellular architecture of the rat thymus is through the use of Formalin-Fixed Paraffin-Embedded (FFPE) blocks. ...
However, the same proteolytic activity that protects against pathogens can, when unregulated, contribute to tissue injury, autoimmune inflammation, and chronic disease progression. In recent years, recombinant ELANE protein has become an indispensable tool for researchers studying neutrophil function, protease regulation, and disease ...
These proteins are vital for treating conditions such as cancer, autoimmune diseases, and infectious diseases. Beyond therapeutic uses, recombinant proteins are instrumental in research and diagnostics. ...
This phenomenon is crucial in various contexts, including disease pathogenesis and the development of therapeutic interventions. For instance, when a vaccine elicits an immune response against a pathogen, it is vital to ensure that the generated antibodies do not target similar proteins in the body’s own tissues, as this could result in autoimmune ...
These chemokines protein allows researchers to study the functional dynamics of chemokine-receptor interactions in controlled environments, facilitating the development of targeted therapies for a range of diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. ...
In recent years, the field of antibody drug design has become increasingly significant in the realm of therapeutic development, driven by the need for more effective and targeted treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases. ...
Applications of Single-Domain Antibodies Single-domain antibodies have a wide array of applications across multiple fields: Therapeutics: They are being explored as potential treatments for various diseases, including cancer, infectious diseases, and autoimmune disorders, due to their ability to specifically target antigens. ...
Their size, ease of handling, and well-characterized immune system make them ideal candidates for studying disease mechanisms and therapeutic interventions. Understanding the cytokine and chemokine profiles in rats can provide insights into human diseases, as many of the biological pathways are conserved across species. ...
Customized assays can help identify key cytokines involved in immune regulation. Infectious Disease Studies: Cytokines play a significant role in the host response to infections. By measuring cytokine levels, researchers can gain insights into the pathogenesis of infectious diseases and the effectiveness of potential treatments. Autoimmune and ...
This groundbreaking approach unlocks new potential in targeting previously “undruggable” proteins, paving the way for transformative therapies in various diseases. At the forefront of this innovation are specialized PROTAC discovery and screening services, which streamline the pathway from concept to clinical application. ...
Understanding the immune system is fundamental to advancing biomedical research, especially in areas such as cancer, autoimmune diseases, and infectious diseases. Mouse models play a pivotal role in this field, as their immune system shares many similarities with that of humans. ...
This approach is especially beneficial for investigating diseases with immune dysregulation, such as cancer, autoimmune disorders, or infectious diseases, where multiple cytokines orchestrate pathological processes. ...
This characteristic makes hMSCs a promising candidate for treating autoimmune diseases and minimizing tissue rejection in transplant scenarios. ...
These protein drugs exhibit certain biological activity and can prevent, diagnose, and treat diseases in humans, animals, and plants. Compared with small molecular drugs, recombinant protein drugs offer advantages such as high activity, high specificity, and low toxicity, and are therefore favored by researchers. At present, recombinant protein drugs are widely used in various ...
This approach has opened new avenues for immunotherapy, providing hope for treating conditions like cancer, autoimmune disorders, and genetic diseases. Understanding Primary T Cells Primary T cells play a vital role in the body’s defense mechanism. ...
Antibody drugs are a kind of drugs that treat diseases through artificially synthesized antibodies, achieving therapeutic purposes by specifically binding with target molecules. ...
Glycan Profiling in Disease Diagnosis Glycan microarrays are increasingly being used for glycan profiling in disease diagnosis, particularly in cancer and infectious diseases. ...
They have shown great potential in treating various diseases, such as cancer, autoimmune diseases, infectious diseases, and metabolic disorders. ...