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Chronic Disease Articles & Analysis
123 articles found
Key pathologies associated with excessive ELANE activity include: l Chronic obstructive pulmonary disease (COPD): ELANE-mediated degradation of lung elastin contributes to alveolar destruction and emphysema. ...
In soft tissues like arteries, unregulated hydroxyapatite accumulation leads to vascular calcification, a pathological condition associated with atherosclerosis, diabetes, chronic kidney disease (CKD), and aging. Studies in MGP-knockout mice have shown extensive arterial calcification and premature death, underscoring the importance of this protein in ...
As research advances, next-generation PEGylation techniques promise safer, more effective therapies for diverse diseases, from cancer to chronic inflammatory conditions. By overcoming current limitations, PEGylation will continue to play a pivotal role in the future of biopharmaceuticals. ...
A New Drug to Reduce Heart Attacks and Strokes The newly approved drug Sotagliflozin (Inpefa) has shown promise in reducing heart attacks and strokes among patients with type 2 diabetes and chronic kidney disease. It works as a dual SGLT1 and SGLT2 inhibitor, helping to regulate blood sugar levels while also protecting the heart. ...
Smokers significantly increase the risk of developing Chronic Obstructive Pulmonary Disease (COPD) and lung cancer, as well as heart disease. ...
Why Is NAD/NADH Analysis Important? Metabolic Health and Disease Research Alterations in NAD/NADH levels are associated with a wide range of diseases, including cancer, diabetes, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), and mitochondrial diseases. ...
It has been reported to be effective in treating chronic pain conditions, including fibromyalgia and chronic back pain. ...
Elastase in Pathological Conditions One of the most well-studied conditions involving elastase is emphysema, a form of chronic obstructive pulmonary disease (COPD). In emphysema, excessive activity of neutrophil elastase results in the degradation of elastin in the lung's alveolar walls, leading to impaired lung function and reduced elasticity. ...
This test is commonly used to monitor a patient's immune response to biological agents or other drugs, especially in the treatment of chronic diseases such as autoimmune diseases, certain cancers, and inflammatory diseases. ...
MMPs are involved in pathological processes such as hypertension, eclampsia, vascular inflammation, atherosclerosis, coronary syndromes and myocardial infarction, cerebral ischemia and ischemic stroke, peripheral arterial disease, aneurysms, chronic venous disease, etc. MMPs can be used as biomarkers and potential therapeutic targets for certain ...
Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of diabetes is increasing year by year. ...
Evaluating the stress related effects of various restraint methods in rodents Any restraining device used in an inhalation exposure set-up will be, by definition, restricting the subject’s ability to move. For nose-only inhalation set-ups, typical restraints are rigid, fully enclosed and include a metal or acrylic plunger forcing the subject forward and preventing the subject from ...
Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of synovial joints. Anticitrullinated protein autoantibodies are detected by the CCP test in early disease and predict the development of erosive disease as well as extraarticular manifestations. ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. ...
These engineered T cells selectively recognize and eliminate CD19-positive B cells. 2) Chronic Lymphocytic Leukemia (CLL): In CLL, a type of chronic lymphocytic leukemia, the majority of patients display CD19 on the surface of leukemia cells. ...
Treatment of Cystic Fibrosis CF is a chronic and progressive disease with no known cure, but there are several treatments available that can help manage the symptoms and improve the quality of life for people with the disease. ...
The field of medical science has long utilized disease models, which are systems simulating the progression and expression of a disease, to better understand various illnesses. ...
Investigating the cellular and molecular interplay between cytokines and diseases, particularly autoimmune diseases and tumors, yields insights crucial for guiding clinical diagnosis and treatment strategies. ...
Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide. ...
Clinical Applications of MMP-3 MMP-3 and Rheumatoid Arthritis (RA) Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial cell proliferation and infiltration of lymphocytes, leading to destruction of joint cartilage and bone erosion. ...