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Clinical Assessment Articles & Analysis
31 articles found
Characterization is essential for confirming that iPSCs exhibit properties consistent with embryonic stem cells (ESCs). Morphological Assessment Initially, iPSCs can be assessed morphologically. They typically present a distinct colony structure characterized by tightly packed cells with a large nucleus-to-cytoplasm ratio and prominent nucleoli. ...
However, the execution of cell and gene therapies is veiled in complexities. The prime concern resides in assessing the clinical efficacy of these therapies, as their long-term impact is yet to be conclusively quantified. Hence, an extensive lattice of regulations envelops these modalities, mandating rigorous preclinical studies and clinical ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform ...
In England, approval from the National Institute of Health and Care Excellence (NICE) demonstrates that a device or medicine has been assessed by independent committees and has made evidence-based recommendations for the health and social care sector1. Technology appraisals2 assess the clinical and cost-effectiveness of health technology, ...
By targeting specific pathways critical to the growth and survival of the excretory system, the scientists aim to develop more effective and less toxic treatments for brain excretory mechanisms. At the same time, pre-clinical studies are also significant to assess the efficacy and safety of small molecule drugs in brain cancer before they enter ...
However, the execution of cell and gene therapies is veiled in complexities. The prime concern resides in assessing the clinical efficacy of these therapies, as their long-term impact is yet to be conclusively quantified. Hence, an extensive lattice of regulations envelops these modalities, mandating rigorous preclinical studies and clinical ...
Before a new drug candidate can progress to clinical trials and ultimately reach the market, it needs to undergo rigorous testing in various model systems to assess its efficacy and safety. ...
Furthermore, MMP-3 is a reliable biomarker for assessing disease activity, imaging monitoring, predicting disease outcomes, and treatment response in rheumatoid arthritis [4]. ...
Serum enzyme tests have been used in clinical practice for a long time, such as increased amylase activity in serum and urine of patients with acute pancreatitis. ...
Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have signs and symptoms of HF as the result of high left ventricular (LV) filling pressure, despite normal or near-normal LV ejection fraction (EF). ...
A report on the use of the Doraya catheter in 2 patients demonstrated an increase in urine output in patients with initial poor diuretic response following placement of the catheter.69 A first in man clinical study is currently ongoing to assess feasibility, safety, and hemodynamic effects in patients with ADHF.70 Selective (S) Direct intrarenal delivery of ...
With the rising demand for improving patient safety in clinical trials, the adoption of patient-centric solutions is considered the best route to enhance data accuracy and experience automated workflows. ...
ByClinion
The changes the regulation brings companies need to already be reviewing their current processes, systems and supporting infrastructure for clinical trial applications and operations. They need to do so in every changing regulatory environment where Clinical Trial and related data is being ever more scrutinized. ...
ByDDi LLC
The ability to predict how a clinical trial participant will adhere to their treatment, and even respond to that treatment, has great promise to advance patient-centric clinical research. ...
ByAiCure
Methods We did a pilot study at three hospitals in Shanghai to assess the accuracy of pulse oximetry plus clinical assessment for detection of congenital heart disease. ...
HYPOTHESIS: The aim of this study was to determine the diagnostic yield of a patient-triggered CER combined with continuous automatic arrhythmia detection in the evaluation of sporadic dizziness/syncope or palpitations and its clinical relevance in assessing the further management. METHODS: We investigated 101 consecutive outpatients (54 +/- 20 years, 40 ...
ByNovacor
When promising drug candidates are identified for further investigation in clinical trials, sponsor companies are usually optimistic about outcomes. ...
Imagine you’ve just been diagnosed with cancer and you’re enrolled in a clinical trial for a promising new drug. You notice that after chemotherapy you struggle with occasional fatigue. ...
ByAiCure
The DASCOR Disc Arthroplasty Device seemed to perform well clinically but was discontinued in 2009. While there are no commercially available NRDs today, the potential advantages of using such devices have prompted a renewed interest in further developing the technology and assessing long-term outcomes for the DASCOR device. Methods A retrospective review of ...
We developed a decision-analytic Markov model for assessing the clinical and economic consequences of pDVA compared to conventional “status quo” treatment. ...