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Immune Functional Articles & Analysis
52 articles found
They simulate parts or functions of pathogens, enabling the immune system to rehearse future infections so that it can respond rapidly upon actual exposure, effectively preventing disease occurrence or reducing severity. ...
Acting as chemoattractant molecules, chemokines are central to both innate and adaptive immunity, influencing not only immune surveillance but also wound healing and angiogenesis. ...
Central Nervous System APIs address neurological and psychiatric conditions by modulating neurotransmission, receptor function, and neural signaling pathways. This category encompasses antidepressants, antipsychotics, anxiolytics, anticonvulsants, and cognitive enhancers, each designed to cross the blood-brain barrier and interact with specific neural targets. ...
This provides an innate channel and repository for transporting pharmaceuticals. Platelets naturally function as superior drug carriers because of the unique receptors on their surface. ...
In vitro testing involves studying immune responses in controlled laboratory environments using cell cultures. ...
Mouse models play a pivotal role in this field, as their immune system shares many similarities with that of humans. A key aspect of studying the immune system involves analyzing cytokines, chemokines, and growth factors—molecules that regulate immune responses and influence disease progression. The Mouse Luminex Cytokine Assay has emerged ...
Sleep apnea is a sleep disorder that is characterized with snoring and frequent interruptions in breathing, when asleep. That impacts quality sleep and puts the individual at risk of health issues. Though CPAP therapy is considered gold standard in treating sleep apnea, there are a multitude of vitamins and minerals that can help you get better sleep by addressing factors like muscle relaxation ...
In immunological research and drug discovery, it is essential to have reliable tools to study the function of immune receptors and their role in various diseases. Immune receptor stable cell lines are engineered cell lines that have permanently integrated a single type of immune receptor gene into their genome. This allows for ...
Antigens are molecules or molecular structures that evoke an immune response when identified as foreign by the body's immune system. ...
The antibody sequence can be used to create vaccines, develop new treatment strategies, and even analyze the functioning of the immune system. Below is the basic process of discovering new antibodies through sequencing.Prepare SamplesImmune cell samples, such as lymphocytes, are obtained from the patient or experimental animals. These cells are the sources of ...
Especially when the host's own tissues express target antigens, the phenomenon of immune tolerance may hinder the stimulation of effective immune responses, thereby increasing research difficulty. ...
The Constant Region of an antibody is a part of the immunoglobulin (antibody) molecule, responsible for stabilizing the structure of the antibody to execute its specific immune function. The constant region of an antibody is usually at the bottom of the molecule, close to the tail of the antibody, corresponding to the variable region of the antibody, which is ...
To ensure the effectiveness and safety of these antibody drugs, it is necessary to perform activity testing.Definition of Antibody ActivityThe activity of an antibody drug usually refers to its ability to bind to the target antigen and how it affects the target in a biological function, such as neutralizing viruses, killing tumor cells, or regulating immune ...
T cells are the most numerous and functionally complex type of lymphocytes, mainly including CD4+ T cells and CD8+ T2 cells, which play an important role in cellular immunity and assist in humoral immune response. ...
Each of these components plays a crucial role in supporting various physiological functions in the human body, and their supplementation can help to fill nutrient gaps and promote overall health. ...
Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen. ...
Cytokines not only enhance the expansion and persistence of CAR-T cells, but also enhance their function in immunosuppressive TME. Cytokines, including interleukins, tumor necrosis factor, interferons, chemokines, colony-stimulating factors, growth factors, etc., are involved in the activation, proliferation, differentiation and survival of various immune ...
CD73, also known as ecto-5′-nucleotidase, is a groundbreaking immunoinhibitory protein that assumes a pivotal role in tumor growth and metastasis. Its primary function revolves around converting extracellular ATP into immunosuppressive adenosine, working in tandem with CD39 within normal tissues to curtail excessive immune reactions. ...
Biological Significance of Glycosylation Changes in the glycan composition and structure of Fc-Fusion can cause conformational changes in the structural domain of Fc, which can alter its binding affinity to the Fcγ receptor and consequently lead to functional changes in immune effectors. Fc-mediated antibody effector functions include ...
It serves as a crucial marker for B cells, playing a pivotal role in the human immune system. While predominantly found on the surface of B cells, CD19 is rarely expressed on other immune cells. ...