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In Vivo Use Articles & Analysis
29 articles found
Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be achieved in mice and cell culture systems. ...
Computer SimulationIn recent years, computer simulation technology has been increasingly used in antibody research and is often used to screen, select, and optimize potential antibody sequences after discovery activities. ...
Studying the distribution of DAR values helps to understand the overall fate of ADCs and provides a theoretical basis for ADC biotransformation in vivo. UV/VIS spectroscopy is widely used to determine antibody concentration and DAR value, but this method is a buffer system and cannot be applied to complex biological systems such as plasma/serum. ...
Among the numerous tools employed are "reporter systems," which use a visible marker to track gene expression, protein interactions, and other vital biological processes. One such system employs reporter lentiviral particles, using the power of viral vectors to inject and express these markers in target cells. ...
Traditional vaccines rely on the use of inactivated pathogens to trigger an immune response. However, many of these formulations carry a high risk of causing allergies or autoimmune reactions. ...
The main types of viral vectors used clinically for in vivo gene therapy include adenovirus, adeno-associated virus (AAV), herpes simplex virus (HSV), retroviruses, and lentiviruses. ...
Moreover, the personalized 3D human cardiac tissue models empower researchers to conduct drug safety and efficacy analysis using enriched study population at preclinical stages. IVS has developed an in vitro disease model that recapitulates an individual patient’s cardio myopathy in 3D EHTs using patient-derived cells. ...
Bacteriocins are strong candidates for use as future therapeutics. Recent studies have shown that bacteriocins have exemplary antibacterial activity in vitro. Nonetheless, the next step in developing new bacteriocin-based therapeutics involves the use of in vivo models. The antibacterial and/or toxic effects of bacteriocins have been studied in ...
Other CPPs present additional advantages such as tumor-homing, penetration through the blood-brain barrier, and antimicrobial activity. l FeaturesThe most remarkable feature of cell-penetrating peptides is that it’s able to penetrate the cell membrane at low micromolar concentrations in vivo and in vitro, without using any chiral receptors and without causing ...
The researchers discovered distinct sets of amygdala neurons active during action-consuming sequences using in vivo deep brain Ca2+ imaging and electrophysiology. For behaviorally relevant information, these sets were mixed spatially and propagated to multiple striatal subregions. ...
A Novel, High-Throughput Platform to Characterize Novel IBD Therapeutics Altis’ RepliGut® Planar platform provides a novel, human primary culture cell system that both reprises the cellular complexity of the intestinal tract in vivo which is established using 12- and 96-well Tranwells® inserts to maximize throughput and dosing/assay flexibility. ...
Precautions All MyBioSource products are for scientific laboratory research purposes and not for diagnostic, therapeutic, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Product purchased from MyBioSource in accordance with industry standards. ...
Both current in vitro and in vivo models used in the development of candidate therapies for the treatment of intestinal diseases have severe limitations. ...
Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone, time and cost intensive and lack reproducibility in clinical settings. ...
The use of inappropriate model systems in drug development can result in ineffective drugs reaching clinical trials and the failure to investigate potentially useful therapeutics. ...
The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment in the alleviation of colitis using the in vivo dextran sodium sulfate (DSS)-induced colitis mice model. ...
More efficient development of drugs with attractive side effect profiles requires robust, easy-to-use, cost-effective in vitro gut models that are physiologically representative of the human intestinal tract and thus predictive of in vivo behavior. ...
Therefore, we evaluated the effects of Lactobacillus fermentum (L. fermentum) KBL375, isolated from the feces of healthy donors (Jang et al., 2019), for AD treatment using an in vivo house dust mite (Dermatophagoides farinae, DFA) extract-induced AD mouse model using NC/Nga mice. ...
End users must see the benefits in using the new system. If it doesn’t save time or make their job easier, they will not be enthusiastic adopters. ...
The US Environmental Protection Agency has responsibility for assessing endocrine activity of more than 10 000 chemicals, a task that cannot reasonably be achieved solely through use of available mammalian and nonmammalian in vivo screening assays. Hence, it has been proposed that chemicals be prioritized for in vivo testing ...