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Bone Formation Articles & Analysis
12 articles found
Posterolateral Rabbit Spinal Fusion Study I. Introduction Autologous bone has long been the gold standard for bone graft substitute in spinal fusion procedures. The limited supply and morbidity associated with using autologous graft material led to the development of alternative bone grafting materials. Bioactive glass has a long history of biomedical use and has been shown to facilitate mineral ...
Structure of Matrix Metalloproteinase (MMP) Family In vertebrates, the MMP family consists of 28 members, at least 23 of which are expressed in human tissues, 14 of which are expressed in the vascular system. MMPs are usually classified into collagenases, gelatinases, stromelysins, matrilysins, membrane-type (MT)-MMPs, and other MMPs based on their substrates and the organization of their ...
Introduction to OsteoporosisOsteoporosis is a systemic multi-causal skeletal disease that is prone to fractures due to changes in systemic bone mass and microstructure of bone tissue, resulting in increased bone fragility. Osteoporosis is a type of disease that is difficult to cure. According to the etiology, it can be divided into primary osteoporosis, secondary osteoporosis and idiopathic ...
Summary: Non-union of bone fractures can cause pain and disabilities. Amongst certain fracture types, in specific age groups, the incidence of non-union is over 8% in the United States and over 3.6% of all fractures in the UK. Fracture non-unions have lifelong consequences and a debilitating impact in patients' life. Bone-grafts, allografts and xenograft are currently used to treat bone ...
As an important branch of biomedical materials, bioceramics are mainly used to manufacture hard tissue repair devices and artificial organs in vivo, and generally have good biocompatibility. According to the chemical activity in the physiological environment, bioceramics can be divided into three types: Nearly inert bioceramics, only weak or no chemical reaction occurs when exposed to the ...
ByMatexcel
ABSTRACT Previous subgroup analyses from the ACTIVE trial in women with postmenopausal osteoporosis (NCT01343004) using three-dimensional (3D)-processing of dual X-ray absorptiometry (DXA) scans indicated greater increases in total hip cortical volumetric bone mineral density (Ct.vBMD) and estimated indices of hip strength following 18 months of abaloparatide (ABL) versus placebo or ...
By combining different cell populations in a fibrin bioink, researchers from Trinity College Dublin, Royal College of Surgeons in Ireland and University of Illinois Chicago were able to sprout an in vitro microvessel network that was then exploited to prevascularise a 3D printed scaffold implanted in a critical size femoral defect using REGENHU bioprinter. This dual approach was observed to ...
ByRegenhu
Mesenchymal stem cells (MSC) differentiate towards multiple lineages that participate in bone formation and are often utilized for bone regeneration therapy. A 2019 review by Lee et al. explores the endogenous mechanical and biochemical environment of MSCs. Additionally, the article highlights the essential factors that lead to bone repair and how these factors can be leveraged to improve bone ...
Osteogenesis, or new bone formation, begins in the early stages of embryonic development and continues postnatally until skeletal maturity is reached in early adulthood. Osteogenesis reoccurs in the event of bone trauma, such as a fracture or surgically created defect. Bone mass can also increase in response to chronic weight bearing from daily use or decrease due to a lack of movement or applied ...
Abstract Polyetheretherketone (PEEK) is currently gaining popularity in orthopedic and spinal applications but has potential drawbacks in use. PEEK is biocompatible, similar in elasticity to bone, and radiolucent; however, it has been shown to be inert and does not integrate well with bone. Recent efforts have focused on increasing the bioactivity of PEEK by modifying the surface to improve the ...
Leptin plays a role in foetal growth. Osteocalcin, a bone specific protein, reflects bone formation rate. This study aims to investigate the effect of leptin and osteocalcin on physical growth of newborns. About 40 full-term and 41 preterm healthy babies were included. Umbilical cord samples were analysed for leptin and osteocalcin. Anthropometric measurements were taken on newborns. Leptin was ...
Kremen1 and Kremen2 (Krm1 and Krm2) are transmembrane coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/β-catenin signaling. The physiological relevance of Kremen proteins in mammals as Wnt modulators is unresolved. We generated and characterized Krm mutant mice and found that double mutants show enhanced Wnt signaling accompanied by ectopic postaxial forelimb digits and expanded apical ...