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Antibiotic Penicillin Articles & Analysis

4 articles found

The Role of Nitrogen Compounds in Antibiotic Development

The Role of Nitrogen Compounds in Antibiotic Development

β-Lactam Antibiotics Representative Compounds: Penicillin, Cephalosporins Application: β-lactam antibiotics incorporate a nitrogen-containing β-lactam ring that plays a vital role in combating bacterial cell wall synthesis. ...

ByBOC Sciences


Design and R&D of Covalent Drugs

Design and R&D of Covalent Drugs

Although covalently drugs have only become popular in recent years, the concept is not uncommon in nature. Many antibiotics, such as penicillin, showdomycin and fosfomycin, interact with their targets in bacteria in the form of covalent bonds. ...

ByBOC Sciences


Laea, a regulator of secondary metabolism in aspergillus spp

Laea, a regulator of secondary metabolism in aspergillus spp

Deletion of laeA (laeA) blocks the expression of metabolic gene clusters, including the sterigmatocystin (carcinogen), penicillin (antibiotic), and lovastatin (antihypercholesterolemic agent) gene clusters. Conversely, overexpression of laeA triggers increased penicillin and lovastatin gene transcription and subsequent product formation. laeA ...

ByAmerican Society for Microbiology (ASM)


Laea, a regulator of secondary metabolism in aspergillus spp.

Laea, a regulator of secondary metabolism in aspergillus spp.

Deletion of laeA (laeA) blocks the expression of metabolic gene clusters, including the sterigmatocystin (carcinogen), penicillin (antibiotic), and lovastatin (antihypercholesterolemic agent) gene clusters. Conversely, overexpression of laeA triggers increased penicillin and lovastatin gene transcription and subsequent product formation. laeA ...

ByAmerican Society for Microbiology (ASM)

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