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Antigen Expression Articles & Analysis
31 articles found
By binding to these antigens, antibodies can neutralize pathogens directly or mark them for destruction by other immune cells. ...
These technologies allow scientists to cut, insert, or modify specific DNA sequences, enabling the customization of T cells to recognize and attack disease-specific antigens. Applications in Cancer Therapy One of the most promising applications of gene editing in primary T cells is in cancer therapy. By engineering T cells to express chimeric ...
The principle is to clone one or several antigen genes of a pathogen into host cells, causing them to express the corresponding antigen protein. ...
One promising strategy is to deliver genes that express tumor suppressor proteins or anticancer agents into cancer cells to induce cell death or inhibit their proliferation. In addition, gene delivery can be used to modify vulnerable cells, analogous to T cells, to express antigen receptors that specifically kill cancer cells. Overall, gene ...
Recombinant protein vaccines are vaccines prepared by expressing and purifying the antigen proteins of pathogens in engineered cells (such as bacteria, yeast, mammalian cells, and insect cells) using genetic engineering technology. ...
Compared with the original library, libraries derived from immune donors can produce antibodies with higher expression levels, stronger affinity, and specificity for target antigens, injecting new vitality into the development of antibody drugs. ...
Recombinant protein vaccine is a type of vaccine that does not contain complete pathogens and is prepared from specific protein antigens produced by heterologous expression systems. Due to their advantages of good safety, strong stability, and relatively low cost, recombinant protein vaccines have been widely favored by researchers in recent years. ...
FC analysis can characterize individual cells in terms of cell surface or internal antigen expression, subcellular components (such as mitochondria), and cell dynamic properties (such as changes in protein expression, calcium flow, membrane potential, and cell proliferation). ...
Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. ...
MECP2 is a DNA-binding protein that plays a role in the epigenetic regulation of gene expression. These mutations lead to immature synapses in the cerebral cortex, abnormal metabolism of cholesterol in the brain leading to abnormal neuronal development, and abnormal neuronal signaling. ...
An antibody drug conjugate (ADC) consists of three core elements: an antibody that targets a target antigen, a cytotoxic payload, and a linker that binds the two. Potent cytotoxic drugs can be targeted to tumor cells with chemotherapeutic cytotoxic properties by means of selective monoclonal antibodies against specific or preferentially expressed ...
Targets can be divided into tumor-specific antigens (TSA) and tumor-associated antigens (TAA) according to their expression. Antigens that are only expressed in tumor cells but not in normal cells are tumor-specific antigens and the most ideal targets; antigens that are lowly ...
ADCs usually consist of a fully humanized monoclonal antibody (mAb), a cytotoxic drug, a suitable linker, and an antigen specifically expressed on tumor cells. In 2000, the FDA approved the first ADC molecule, Gemtuzumab ozogamicin, for the treatment of AML. ...
In this approach, a patient’s T cells are extracted and purified from a blood sample; they are subsequently genetically modified to express a T-cell receptor specific to a tumor antigen unique to the patient’s cancer cells. ...
STEAP1, TROP2, PSMA, CD46, and B7-H3 are currently being looked at as optimal antigens, which have been shown to be targeted by ADCs. 1. ADC For The Treatment of PCa PSMA-based ADCs PSMA (prostate-specific membrane antigen) is a cell membrane protein specifically expressed by prostate cells, and its expression in PCa and ...
Driven by basic research in oncology and immunology, the selection of ADC target antigens has gradually expanded from traditional tumor cell antigens to targets in the tumor microenvironment, such as stroma and blood vessels. ...
Mesothelioma and ovarian cancer have the highest expression of mesothelin, and higher expression is associated with advanced tumor stage and higher metastasis rate. ...
However, some cancer subtypes are relatively resistant to NK cell cytotoxicity. Expression of anti-CD19 chimeric signaling receptors can enhance NK-cell reactivity against CD19+ leukemia and lymphoma cells. Here we describe a method to enforce expression of such receptors in human NK cells relying on electroporation of mRNA and compare it to retroviral ...
In addition, oral administration of liposome-antigen formulations may enhance antigen delivery to antigen-presenting cells.Topical drug administrationLiposomes can reduce the side effects of topical drugs because they require only small doses when used as topical formulations. ...
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. ...