Antigen Gene Articles & Analysis
7 articles found
This host cell, often a yeast or bacteria, then produces antigens that mimic the pathogen’s characteristics. When administered, these antigens stimulate the immune system to recognize and combat the actual pathogen without causing disease. One notable example is the use of the hepatitis B virus surface antigen. By inserting the relevant ...
The principle is to clone one or several antigen genes of a pathogen into host cells, causing them to express the corresponding antigen protein. ...
One method is introduction of a viral gene that partially deregulates the cell cycle, such as EBV, SV40 T antigens and HPV-16 E6/7 gene. The cellular gene encoding human telomerase reverse transcriptase (hTert) has been successfully used for the expansion of several cell types that retain important properties in vitro. However, ...
The gene consists of 15 exons and codes for the CD19 molecule comprising 556 amino acids. ...
The introduction rule uses genetic engineering and protein engineering to introduce a catalytic gene into the antigen binding site of a specific antibody to obtain a catalytic function. The copy method is mainly designed according to the antigen-antibody complementarity during the antibody production process. ...
We tested the potency of these compounds in altering the interaction of CTLA-4 with its ligands in a reporter cell system with effector Jurkat cells carrying a luciferase gene and antigen presenting Raji cells. Compounds binding to CTLA-4 blocked the interaction of CTLA-4 with its ligands and resulted in increased luminescent signal. ...
Plasmodium falciparum imposes an enormous burden upon the developing world, with 300 to 500 million cases and 1 to 2 million deaths per year (94). Despite extensive esearch efforts, development of parasite drug resistance is a growing problem, and an ffective vaccine is still lacking. Individuals living in areas of high P. falciparum ransmission acquire protective immunity to severe ...