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Antigen Protein Articles & Analysis
11 articles found
These studies aim to identify whether antibodies or T cells generated against a particular antigen react with similar proteins found in different tissues, which can lead to unintended effects and complications. ...
Since its first FDA-approved application in 1990 with Adagen® (pegademase bovine), PEGylation has been widely adopted in biopharmaceuticals, including proteins, peptides, antibodies, and nanoparticles. This article explores the mechanisms, benefits, challenges, and future prospects of PEGylation in drug development. ...
In recent years, the field of antibody drug design has become increasingly significant in the realm of therapeutic development, driven by the need for more effective and targeted treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases. Antibodies, which are proteins produced by the immune system, have the ability to specifically recognize ...
Recombinant protein vaccines are vaccines produced using genetic engineering technology. The principle is to clone one or several antigen genes of a pathogen into host cells, causing them to express the corresponding antigen protein. ...
Recombinant protein vaccines are vaccines prepared by expressing and purifying the antigen proteins of pathogens in engineered cells (such as bacteria, yeast, mammalian cells, and insect cells) using genetic engineering technology. Compared with other types of vaccines, recombinant protein vaccines are more costly but have ...
This enzyme ensures the accurate synthesis of mRNA strands that encode the desired antigen, typically a viral protein. The precision of RNA polymerase is critical, as any errors in the mRNA sequence could lead to ineffective or unsafe vaccines. ...
Recombinant protein vaccine is a type of vaccine that does not contain complete pathogens and is prepared from specific protein antigens produced by heterologous expression systems. ...
Adjuvants are substances that are added to vaccines to enhance the body's immune response to the antigen (the protein that triggers an immune response). Adjuvants work by stimulating the innate immune system, which can lead to a stronger and longer-lasting immune response. In the case of mRNA vaccines, adjuvants can help boost the immune response to the ...
In these computer-based methods, the primary amino acid sequence or 3D structure of antigen proteins from the target pathogen is used as input to analyze the existence of sequences (epitopes) capable of binding to major histocompatibility complex (MHC). In humans, MHC is referred to as human leukocyte antigen (HLA).Assessing Epitope ...
Abera’s vaccine delivery platform works as a plug-and-play system where known or novel antigens can be engineered onto our delivery platform to create effective, multivalent vaccines that are cost-effective and fast to produce. We actively work together with academia and industry to enable the use of our vaccine delivery platform in design and development of new vaccines. Many of these ...
Endosomal escape means that mRNA needs to be released from the endosomal vesicles, and then combined with the host cell ribosome to be translated into antigen proteins, which are modified and secreted out of the cell to play a role. ...