Antigen Receptor Articles & Analysis
32 articles found
Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer cells. ...
Among the various forms of immunotherapy, CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) has shown promise, particularly in treating acute lymphoblastic leukemia (ALL), especially in children and young adults. This therapy involves genetically modifying a patient’s T-cells to express a receptor specific to cancer cells, ...
These technologies allow scientists to cut, insert, or modify specific DNA sequences, enabling the customization of T cells to recognize and attack disease-specific antigens. Applications in Cancer Therapy One of the most promising applications of gene editing in primary T cells is in cancer therapy. By engineering T cells to express chimeric antigen ...
In addition, gene delivery can be used to modify vulnerable cells, analogous to T cells, to express antigen receptors that specifically kill cancer cells. Overall, gene delivery has great eventuality as an important tool for the development of new and personalized cancer drugs technology. ...
As a biology researcher, staying at the cutting edge of technology is crucial to advancing research in the field. The emergence of chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of certain cancers, providing a promising targeted approach to eliminate cancer cells. ...
After intravenous injection, the distribution of mAb from vascular to interstitial space is mainly through convection (fluid flow from the blood to interstitial space) and binding between antibody cells, or through receptor-mediated endocytosis, phagocytosis, and pinocytosis in the liquid phase. ...
The T cell antigen receptor (TCR) is a characteristic marker of T cells, playing a crucial role in the immune system. ...
CAR-T/CAR-NK Cells Development for Drug Delivery Systems As a groundbreaking advancement in immunotherapy, CAR-T (Chimeric Antigen Receptor T-cell) and CAR-NK (Chimeric Antigen Receptor Natural Killer) cells have shown remarkable success in treating certain cancers. These personalized cell therapies involve modifying a ...
Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. ...
Both mouse and human TSLP are predominantly expressed by epithelial cells, with the highest expression levels observed in the lung, skin, and intestine[2]. TSLP receptor (TSLPR), a member of the erythropoietin receptor family, has low affinity for TSLP. ...
When a cell binds both the T-cell receptor (the receptor specific for a given antigen, that gives a T cell its specificity) and the checkpoint molecule (PD-1 in the displayed figure), the T cell becomes inactivated. ...
So far, anti-mesothelin antibody-drug conjugates have been successfully used to treat mesothelin-expressing solid tumors, including ovarian cancer, pancreatic cancer, and malignant mesothelioma; and mesothelin targets chimeric antigen receptor (CAR) T cell therapy also showed significant antitumor effects. ...
Selection of ADC Target Antigens Currently, the target antigens of approved ADC drugs are typically specific proteins that are overexpressed in cancer cells, including HER2, trop2, nectin4, and EGFR in solid tumors, and CD19, CD22, CD33, CD30, BCMA, and CD79b in hematological malignancies. Driven by basic research in oncology and immunology, the selection of ...
Expression of anti-CD19 chimeric signaling receptors can enhance NK-cell reactivity against CD19+ leukemia and lymphoma cells. Here we describe a method to enforce expression of such receptors in human NK cells relying on electroporation of mRNA and compare it to retroviral transduction of cDNA. These methods are applicable to the reprogramming of NK cells with ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Besides the IL-2RG receptor subunit, the γc family cytokine receptors include IL-2RB ...
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. ...
Celdara Medical, LLC today announced that the National Cancer Institute of the National Institutes of Health (NIH) has awarded a Small Business Innovation Research (SBIR) Phase I award to fund the company’s proof of concept studies on a new platform to improve chimeric antigen receptor (CAR) T cells efficacy to treat solid tumors. Dr. Joana ...
Researchers at Massachusetts General Hospital (MGH) have found that interferon gamma receptor (IFNgR) signaling is essential for the susceptibility of CAR-T cell immunotherapy to kill malignant gliomas. ...
At present, chimeric antigen receptor T cell therapy (CAR-T) has made significant achievements in the treatment of specific hematological cancers, allowing patients with relapsed/refractory disease to survive longer and become healthier, but in clinical studies, cell therapy has actually not been successful in the treatment of patients with solid tumors, in part ...
Truncated O-glycans (Tn, TF, and sialic acid Tn antigens), gangliosides (GD2, GD3, GM2, GM3, and rockulose-GM1), globular serine glycans (globo-H, SSEA-3, SSEA-4), Lewis antigens, and polysialic acid are the most well-studied TACAs. ...