Antigen Selection Articles & Analysis
5 articles found
Peptide vaccines are increasingly seen as an economically efficient and safe approach to circumvent this issue.Peptide Vaccine DevelopmentThe vaccine development process is a challenging multi-step process: Antigen selection→Epitope selection→Adjuvant selection→Peptide vaccine synthesis→Immunization study→In vitro ...
Targets can be divided into tumor-specific antigens (TSA) and tumor-associated antigens (TAA) according to their expression. Antigens that are only expressed in tumor cells but not in normal cells are tumor-specific antigens and the most ideal targets; antigens that are lowly expressed in normal tissues but ...
Here, using a genetic timestamping system in mice, we show that persistent PCs accrue in bone marrow at an approximately constant rate of one cell per hour over a period spanning several weeks after a single immunization with a model antigen. Affinity-based selection was evident in persisting PCs, reflecting a relative and dynamic rather than absolute affinity ...
As we all know, both antibodies and enzymes are protein molecules, and the binding of enzymes to substrates and the binding of antibodies to antigens are highly specific. But the fundamental difference between these two binding forms is that enzymes bind to high-energy transition-state molecules, while antibodies bind to antigens (ground-state molecules). ...
A combination of bioinformatics approach and computational tools are used to screen and select antigen sequences as potential T-cell epitopes of supertype human leukocyte antigens (HLAs) alleles. ...