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Biological Contact Material Articles & Analysis
18 articles found
In the fast-evolving field of antibody–drug conjugates (ADCs), linker chemistry plays a decisive role in defining therapeutic performance. The ability to control the drug-to-antibody ratio (DAR), conjugation site, and overall molecular stability directly impacts both efficacy and safety. Among emerging linker materials, azide-functionalized PEG derivatives have become essential tools for ...
Introduction Good Manufacturing Practice (GMP) cell banks play a crucial role in the biopharmaceutical industry, serving as foundational repositories of cell lines used for the production of therapeutic biological products. Characterization of these cell banks is essential to ensure the safety, efficacy, and consistency of the biopharmaceuticals derived from them. This article will explore the ...
Polymers play an important role in the biomedical field, and polyethylene glycol (PEG) and its derivatives are among the multifunctional polymers that have attracted much attention. PEG is a synthetic macromolecule with a linear structure consisting of glycol units (-CH2CH2O-) repeatedly linked. Its unique properties give PEG a wide range of applications. PEG is soluble in organic solvents and ...
The cryogenic process is a method of freezing and storing samples that involves cooling the temperature of biological materials to stop normal cellular processes and prevent sample degradation for long-term storage. The cryogenic process and cryo storage are ideal solutions for the storage of biological samples and ensuring cell viability over ...
Polyethylene (ethylene glycol) is a hydrophilic polymer that can have a very high water content when cross-linked into a network. Polyethylene glycol (PEG) is a suitable material for biological applications because it does not normally elicit an immune response. Since the 1970s, PEG has been used to modify therapeutic proteins and peptides in order to increase their solubility, reduce their ...
Following the coronavirus emergency, surgeries and medical offices shall be reorganised to work safely. One of the first safety measure to adopt concerns suction of aerosol potentially infected. ...
ByAirsafe
The basic requirements of pharmaceutical preparations are safety, efficacy, and stability. Drug stability means that a drug product should maintain the same properties and characteristics as it was at the time of production and within the specified time frame. The stability of pharmaceutical preparations directly affects the effectiveness and safety of drugs. Therefore, it is of great ...
Due to its biological inertness and good biocompatibility, polyethylene glycol (PEG) has a wide range of applications in the pharmaceutical industry, biological materials, cosmetics, and analytical science. A number of compounds, such as proteins, peptides, oligonucleotides, drugs and liposomes, after being modified by PEG covalent bonding, can effectively extend the circulation time in the body, ...
Complex wounds often involve exposed deep structures of the dermal layer, requiring prompt wound closure and tissue reconstruction. It is essential to quickly assess the defect and identify the most effective treatment method for optimizing the patient’s experience and outcome. Often, dermal substitutes are selected as a surgical option for temporizing the wound bed while also facilitating ...
These benefits include: Robust in the presence of infection [1] Unlike biologics, NovoSorb BTM’s synthetic composition does not provide a food source for bacteria Designed to minimize scarring and contracture [1] NovoSorb BTM facilitates the body’s ability to regenerate the dermis Cost-effective alternative to biologics NovoSorb BTM ...
Bioceramic materials have a long history of being used to repair human hard tissues, from biologically inert materials (such as alumina and zirconia, etc.) to biological materials that are both biologically active and degradable (such as phosphate and silicate bioceramics, silicon Based bio-glass, etc.), its physiological function is no longer a simple tissue filling substitute, but a tissue ...
ByMatexcel
ABSTRACT Infection of prosthetic vascular grafts can manifest as pain, pseudoaneurysms, or arterial insufficiency in the leg. We present the case of a female patient with a medical history of a right external iliac artery endofibrosis, with a persistently infected synthetic iliofemoral bypass graft, which we replaced with a bioengineered human acellular vessel. At the 12-month follow-up visit, ...
SARS-CoV-2 detection workflow in wastewater Monitoring wastewater for SARS-CoV-2 – or Coronavirus as it is more commonly known – can be a valuable data resource for an effective COVID-19 management. However, there are several challenges involved in detecting biological parameters in wastewater. Fortunately, there are also several solutions available to overcome them. Wastewater ...
Cause of the Disease Infectious pancreatic necrosis (also known as Acute catarrhal enteritis) is one of the first described and most extensively studied diseases of fish. There are strains and substrains of IPN virus that can be differentiated by serological, biochemical and genetic means. The VR-299 (type 1) strain was originally isolated in North America and has since been found almost ...
Nanobiotechnology refers to the ability to create and manipulate biological and bio-chemical materials, devices, and systems at atomic and molecular levels. Nano delivery systems hold great potential to overcome some of the obstacles in bio-pharmaceutical production, such as water soluble/insoluble pharmaceutical drugs and cosmetic ingredients, risks of toxicity, increasing bio-active efficacy, ...
Nanostructured hydroxyapatite (nHA) exhibits improved mechanical properties and biocompatibility. To optimise the benefits of nano-sized precursors, the particles must have a uniform shape and size and minimum degree of agglomeration. In this study nHA was synthesised using an Iranian strain of Serratia. The powder was synthesised in different pH of reaction solution and incubation temperatures. ...
Xenotransplantation is becoming an independent political and regulatory issue. Most national regulations and international recommendations prescribe a precautionary approach, including strict monitoring and surveillance of patients. This is due to the risk of xenosis, a disease induced by non-human biological material. The paper shows how the precautionary approach violates fundamental principles ...
Biobanks have become one of the core resources for biomedical research. At the same time, a number of risks associated with processing and storing of biological material and corresponding data have been diagnosed. This paper focuses on how institutionalised transnational networks of biobanks generate practical answers to some of these risks. Drawing upon three case studies – GenomEUtwin, ...