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Biomarker Research For Development Articles & Analysis
13 articles found
Alfa Cytology has announced cancer diagnostic biomarker development services to enhance precision in oncology research. ...
These technologies can simultaneously analyze thousands to millions of protein samples, significantly improving the efficiency and accuracy of research. Bioinformatics plays an important role in glycosylation research. ...
Acetylation detection of a specific protein is a method used to determine whether and where acetylation modifications have occurred on a protein. Acetylation is a common post-translational modification of proteins, typically occurring on lysine residues of proteins, and plays a crucial role in regulating protein function, cell signaling, gene expression, and disease onset. For instance, the ...
Cancer is a daunting diagnosis; however, the rapid advancements in oncology are continuously perfecting patient outcomes and quality of life. Among the groundbreaking developments, cancer vaccines are a promising frontier1. These vaccines are transforming how we approach cancer treatment, leveraging the body's immune system to fight malignancies more effectively. ...
Identification of disease biomarkers The most fundamental application of lipidomics in pharmaceutical research is the identification of lipid biomarkers that are associated with lesions in organisms or are expressed abnormally in disease states of organisms. By analyzing the changes of lipid biomarkers throughout the disease ...
Here are some future research directions in the field of CDH1: Mechanisms of CDH1 regulation: Understanding the molecular mechanisms that regulate CDH1 expression and function is essential for developing targeted therapies. ...
Studies have shown that lncRNAs are quite complex in function and play an important role in various biological processes such as development, differentiation, proliferation, metastasis, apoptosis, stem cell pluripotency, and DNA damage. ...
LONDON, June 28, 2021 (GLOBE NEWSWIRE) – Treos Bio Limited (“Treos”), a clinical stage biotechnology company using data science and proprietary biomarkers to develop precision off-the-shelf and personalized peptide cancer immunotherapies, today announced the publication of a peer-reviewed article titled “A Peptide Vaccine Candidate Tailored to Individuals’ Genetics ...
How autoantibody profiling can further unlock the success of CPI therapy Immunotherapy has revolutionised the treatment of cancers, improving the prognosis for a variety of malignancies. One of the key elements in the immunotherapy war chest are checkpoint inhibitors (CPIs) which have been the main drivers behind this progress. These pioneering drugs, however, are not perfect, with a ...
Publication Summary: The identification of targets and biomarkers and development of therapeutics for nonalcoholic fatty liver disease (NAFLD) may be accelerated by the use of well-characterized primary cell and tissue reagents, as well as improved in vitro human cell-based disease models, including three-dimensional (3D) bioprinted liver tissue. The characteristics of donors from which the ...
Broad-spectrum matrix metalloproteinase (MMP) inhibitors (MMPI) were unsuccessful in cancer clinical trials, partly due to side effects resulting from limited knowledge of the full repertoire of MMP substrates, termed the substrate degradome, and hence the in vivo functions of MMPs. To gain further insight into the degradome of MMP-14 (membrane type 1 MMP) an MMPI, prinomastat (drug code AG3340), ...
This study was conducted in a contained environment in order to develop biomarkers and to evaluate the environmental damage after a release of two different toxic substances which are widely used in industrial production. In a simulation study performed in Tor Mancina area (near Rome, Italy), two dangerous substances (formaldehyde and bromine) were tested. Chemical and physical characterisation, ...
Organic contaminants are continually entering aquatic environments and thence the tissues of resident biota. Mussels and other molluscs are used worldwide as sentinels in pollution monitoring. Recent years have seen the development of biological measurements (biomarkers) as tools for use in monitoring and environmental impact assessment, such biomarkers being indicative of contaminant exposure ...