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Biopharmaceutical Articles & Analysis
106 articles found
In the fast-evolving field of antibody–drug conjugates (ADCs), linker chemistry plays a decisive role in defining therapeutic performance. The ability to control the drug-to-antibody ratio (DAR), conjugation site, and overall molecular stability directly impacts both efficacy and safety. Among emerging linker materials, azide-functionalized PEG derivatives have become essential tools for ...
In modern biopharmaceutical manufacturing, downstream processing development has become one of the most critical and resource-intensive stages. ...
In the ever-evolving field of biopharmaceuticals, the production of antibodies has taken center stage due to their critical role in therapeutic applications. ...
Recombinant protein expression is a cornerstone of modern biopharmaceutical development, providing the means to produce proteins with therapeutic potential, enzymes, and antibodies. ...
Antibody-drug conjugates (ADCs) combine potent small-molecule drugs with monoclonal antibodies for targeted cancer therapy. A major challenge is loading enough drug onto each antibody without compromising solubility or circulation time. Introducing polyethylene glycol (PEG) linkers between the antibody and drug payload can address this. PEG is hydrophilic, biologically inert, and FDA‐recognized ...
Since its first FDA-approved application in 1990 with Adagen® (pegademase bovine), PEGylation has been widely adopted in biopharmaceuticals, including proteins, peptides, antibodies, and nanoparticles. ...
This platform is designed to facilitate collaboration between researchers, clinicians, and biopharmaceutical companies, ensuring that breakthroughs in immunotherapy can be efficiently translated into clinical applications. ...
Watertown, MA – March 24, 2025 – Biopharma PEG, a leading supplier of high-quality polyethylene glycol (PEG) derivatives, highlights its innovative product DSPE-PEG-Mannose, an advanced biomedical polymer with significant potential in drug delivery, tumor-targeted therapy, tissue recognition, and adhesion.Structural Advantages of DSPE-PEG-MannoseDSPE-PEG-Mannose is composed of three key ...
Introduction Good Manufacturing Practice (GMP) cell banks play a crucial role in the biopharmaceutical industry, serving as foundational repositories of cell lines used for the production of therapeutic biological products. Characterization of these cell banks is essential to ensure the safety, efficacy, and consistency of the biopharmaceuticals derived from ...
In addition, MtoZ Biolabs also provides a variety of biopharmaceutical characterization services such as activity detection, structure characterization, charge heterogeneity characterization, and impurity analysis. ...
For example, amino acids and proteins are important raw materials for cell growth and antibody production, while sugar provides the energy needed by cells.The analysis of medium components is a key aspect of the biopharmaceutical process because it directly affects the health and productivity of cells and the quality of the final product. ...
Ion chromatography (IC) is an analytical technique used to separate and quantify ionic and polar analytes. IC has become widely accepted by the pharma industry and regulatory bodies for an expanded range of applications like water quality and chemical analysis. It has qualified in recent years to analyze pharmaceuticals. The United States Pharmacopeia-National Formulary (USP-NF, US Pharmacopeia ...
ByB&W Tek
Creative Bioarray has extensive experience in characterizing cGMP cell banks for biopharmaceutical production, offering a broad range of cell line characterization services that allow researchers to efficiently streamline cGMP-compliant manufacturing and accelerate successful commercialization. ...
In addition, MtoZ Biolabs also provides a variety of biopharmaceutical characterization services such as circular dichroism, nuclear magnetic resonance analysis, and we welcome your consultation.Endogenous Fluorescence Detection of Recombinant Protein ...
Furthermore, MtoZ Biolabs also offers a variety of biopharmaceutical characterization services, such as circular dichroism, X-ray, and nuclear magnetic resonance analysis, please feel free to inquire in detail.Endogenous Fluorescence Detection of Recombinant Protein ...
Host cell protein (HCP) residual detection refers to the testing of proteins that may remain in the final product and originate from the production cell line (i.e., the "host") during the biopharmaceutical production process. This testing is crucial because these host cell proteins (HCPs) may impact the safety, efficacy, and quality of drug products.In the fields of biotechnology ...
HCP (Host Cell Proteins) residual detection is a key quality control step in the field of biopharmaceuticals, aiming at ensuring that the proteins of the host cells used for producing therapeutic proteins in any cell-based production system are maintained at acceptable low levels in the final drug product.ImportanceHCPs are impurities during the production process, which may ...
Host protein residue detection is an important quality control step in the biopharmaceutical process. In biopharmaceuticals, cell lines (hosts) are typically used to produce proteins or other biological products. ...
For instance, when producing biopharmaceuticals like monoclonal antibodies, clonality analysis ensures that the production cell line is purely derived from a single, well-characterized clone, thus enhancing product safety and efficacy. ...
In addition, we can provide customized pharmacokinetics services for biopharmaceutical products. ...