Biopharmaceutical Protein Production Articles & Analysis
20 articles found
In the ever-evolving field of biopharmaceuticals, the production of antibodies has taken center stage due to their critical role in therapeutic applications. Among the various production systems available, Chinese Hamster Ovary (CHO) cells have emerged as a gold standard for monoclonal antibody production, and specialized services have been developed to streamline this process. The Significance ...
Antibody-drug conjugates (ADCs) combine potent small-molecule drugs with monoclonal antibodies for targeted cancer therapy. A major challenge is loading enough drug onto each antibody without compromising solubility or circulation time. Introducing polyethylene glycol (PEG) linkers between the antibody and drug payload can address this. PEG is hydrophilic, biologically inert, and FDA‐recognized ...
Introduction Good Manufacturing Practice (GMP) cell banks play a crucial role in the biopharmaceutical industry, serving as foundational repositories of cell lines used for the production of therapeutic biological products. ...
Ion chromatography (IC) is an analytical technique used to separate and quantify ionic and polar analytes. IC has become widely accepted by the pharma industry and regulatory bodies for an expanded range of applications like water quality and chemical analysis. It has qualified in recent years to analyze pharmaceuticals. The United States Pharmacopeia-National Formulary (USP-NF, US Pharmacopeia ...
ByB&W Tek
Indexed sorting data allowed each sequenced cell to be mapped to its native immunophenotype, and these authors found that RNA and cell surface protein expression were not always correlated. Some cells that look similar may have different functions. ...
Host cell protein (HCP) residual detection refers to the testing of proteins that may remain in the final product and originate from the production cell line (i.e., the "host") during the biopharmaceutical production process. This testing is crucial because these host cell ...
Host protein residue detection is an important quality control step in the biopharmaceutical process. In biopharmaceuticals, cell lines (hosts) are typically used to produce proteins or other biological products. ...
Absorption The bioavailability of protein drugs such as antibodies is extremely low after oral administration. The reasons include: 1) Protein is easy to denature in acidic gastric juice; 2) Protein is easily degraded by a large number of hydrolytic enzymes in the gastrointestinal tract; 3) Protein is large and polar, so it is ...
Bioproduction is a critical element in the creation of many vaccines, therapeutics, and other biopharmaceuticals. A central facet of this process involves the development of stable cell lines that are capable of producing these vital products in abundance and with consistency. ...
Amylase converts starches into fermentable sugars, while protease facilitates protein breakdown, influencing the taste and clarity of the final product. ...
Harnessing the power of cell biology, scientists across the globe are perpetually invested in the pursuit of understanding the complexities of cellular mechanisms and their adaptability. One such venture is the creation of Inducible Expression Stable Cell Line (IESCL) development. IESCL signifies a consolidated methodology designed to explore the potentialities of modulated gene expression. This ...
Host cell proteins (HCPs) are process-related impurities produced by host cells and are typically present at low levels in recombinant biopharmaceutical products. ...
Large-scale production of AAV vectors is a multifaceted and critical ordeal of gene therapy production, and understanding the intricate processes is essential for successful scalability and commercial viability. ...
Indexed sorting data allowed each sequenced cell to be mapped to its native immunophenotype, and these authors found that RNA and cell surface protein expression were not always correlated. Some cells that look similar may have different functions. ...
What is "click chemistry"? "Click Chemistry", this is a literary name given to this kind of reaction by the Nobel Prize winner K.Burry Sharless, when the cards are put together, "click" (click). Simply put, it is to add two structures to two molecules respectively, and these two structures can be specifically combined to synthesize the required chemical molecules. One of the most famous ...
Medicine production starts in a lab, where cells are cultured and bacteria fermented in small batches. When it’s time to move to industrial-scale production, Abec – a supplier of bioreactors and fermenters – employs advanced simulation software from Siemens. Abec, a supplier of bioreactors and fermenters, employs advanced simulation software from Siemens ...
Get up close and personal with a Computrac Vapor Pro XL at the 2018 LyoHUB/ASTM E55 Workshop on Pharmaceutical Manufacturing Research. For full information and registration info, visit www.astm.org/E55WorkshopOct2018. You must register by 10/10/18 to attend. About the Event The Workshop on Pharmaceutical Lyophilization will be held Tuesday, October 23, 2018. Sponsored by ASTM Committee E55 on ...
This article estimates the production technical efficiency of pharmaceutical companies and biotechnology companies under heterogeneous technologies. We employ metafrontier analysis to estimate the production metafrontier technical efficiency during the period 1989–2007. When using traditional stochastic frontier analysis, the results show that the technical efficiency of the biotechnology ...
Nanobiotechnology refers to the ability to create and manipulate biological and bio-chemical materials, devices, and systems at atomic and molecular levels. Nano delivery systems hold great potential to overcome some of the obstacles in bio-pharmaceutical production, such as water soluble/insoluble pharmaceutical drugs and cosmetic ingredients, risks of toxicity, increasing bio-active efficacy, ...
Process characterisation is an important aspect of any validation program. This article presents arguments on how process characterisation should be integrated to the process of Research & Development (R&D) itself of a biopharmaceutical product. This makes the work of technical transference and validation easier in the last stages. Although the application of this methodology is time consuming ...