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Bioptic Articles & Analysis
72 articles found
Adenocarcinoma of the breast represents a significant subset of breast cancers, characterized by the malignancy of glandular tissues. This specific article focuses on the right medial segment, highlighting its histopathological features, diagnostic methods, and potential therapeutic avenues. Overview of Adenocarcinoma Adenocarcinomas in the breast typically arise from the epithelial cells lining ...
Immortalized human podocytes represent a significant advancement in the field of renal research, offering scientists an unprecedented opportunity to study kidney function and pathology. These specialized cells play a crucial role in the filtration barrier of the kidneys, and their immortality allows for extended experimentation beyond the limitations of primary cell cultures. Podocytes are unique ...
Circulating Tumor Cells, or CTCs, are cancer cells that have shed from the primary tumor and enter the bloodstream, where they can travel and potentially lead to metastasis. These cells are of significant interest in oncology due to their potential to provide vital information about the tumor’s characteristics and behavior. One of the advanced techniques used to analyze CTCs is Fluorescence ...
Hydrogen and methane breath testing (HMBT) is a non-invasive diagnostic tool frequently used to assess small intestinal bacterial overgrowth (SIBO) and carbohydrate malabsorption disorders such as lactose and fructose intolerance. Despite its widespread use in adults, its application in children is less standardised, and clinicians often face uncertainties about adapting adult protocols for the ...
Colorectal cancer is one of the leading causes of cancer-related deaths globally. To advance our understanding of this disease and improve treatment strategies, researchers heavily rely on colorectal cancer cell lines. These cell lines serve as essential models for studying the biology of colorectal cancer, testing new therapies, and exploring the mechanisms of drug resistance. What are ...
Cell culture is one of the major technologies in the life sciences. It is a general term used to remove cells, tissues or organs from animals or plants and place them in an artificial environment conducive to their survival and/or proliferation. The basic environmental requirements for optimal cell growth are: controlled temperature, substrate for cell attachment, appropriate growth medium and ...
Cancer is a worldwide disease and one of the leading causes of morbidity and mortality today. Traditionally, mouse models have been used for research as in vivo model organisms. However, the zebrafish (Danio rerio), also known as zebrafish, has emerged as an important new cancer model due to its small size, brood weight, and rapid maturation time, complements models that can traditionally be ...
Discover how matched tumor-normal sequencing can help clinical researchers detect the somatic origin of variants with certainty. In the era of precision oncology, it has become increasingly common for patients diagnosed with cancer to undergo tumor sequencing. Identifying the mutations that make up a tumor’s genomic landscape can help guide selection of targeted therapies and inform ...
In response to the emerging needs in global healthcare, SOPHiA GENETICS has just revealed the New Generation SOPHiA DDM™ Platform, aiming to stay at the forefront of precision medicine and address today the healthcare needs of tomorrow. ...
ESMO updated its recommendations for NGS in advanced cancers this year, urging broader use of NGS in additional cancer types and the inclusion of tumor-agnostic biomarkers. The ESMO Precision Medicine Working Group (PMWG) first published its recommendations for when to use next-generation sequencing (NGS) in routine practice for patients with metastatic cancers in 20201. At that time, based ...
Dr. Kate Sasser from Tempus led a discussion on the potential of antibody-drug conjugates (ADCs), their challenges in targeting tumor antigens, and the future of cancer treatment with Dr. Daniel Johnson, Dr. Funda Meric-Bernstam, and Dr. Kellogg Parsons. The oncology field is rapidly advancing with the development of antibody-drug conjugates (ADCs), offering new hope for ...
ByTempus
Contexte Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies directed against components of the muscle membrane located at the neuromuscular junction. In the majority of cases, these are autoantibodies directed against the acetylcholine receptor (AChR). The origin of the autoimmune response is not known, but thymic abnormalities and defective regulation of the ...
X-ZELL is collaborating with Singapore General Hospital (SGH) and the National University Hospital Singapore (NUH) to explore how X-ZELL single-cell diagnostics may aid in the early detection of clinically significant prostate cancer in whole blood. The prospectively blinded, 400-patient multi-centre study officially commenced in 2020 and will lay the foundation for the launch of a commercially ...
Pathology as it is practiced today in labs around the world is not all that different from the pathology of the 19th century. The microscope has changed relatively little since then, and Hematoxylin and Eosin (H&E) stained slides remain the bread and butter of the pathologist. Yet it is not for lack of technological development; in recent years, digital pathology whole slide scanners, digital ...
Medical History Jane is a 40-year-old, married mother of two teenage boys. She teaches at the local elementary school and has been in good health for most of her life. She has no surgical history. Her most severe ailment up to this point has been the flu at age 27. Her students are first-graders; they are often difficult to control. She also experiences the normal stresses of raising ...
Since the 19th century, the practice of tissue processing has remained largely unchanged, resulting in solidified, paraffin-embedded tissue blocks for sectioning. As staining procedures have advanced and immunohistochemistry is becoming more widely used, high-quality tissue sections are paramount for accurate interpretation of disease ...
Patient History This patient was a 68 year old man referred with short segment Barrett's Esophagus (BE) with intramucosal carcinoma (IMC). At the referring center, previous resection of nodularity revealed Tla adenocarcinoma with negative margins. Subsequent surveillance biopsies yielded IMC, and triggered referral. For the procedures described here, standard endoscopy with the addition of ...
Patient History This patient was originally referred with nodular esophageal disease that was endoscopically visible at the Castro-Esophageal Junction (CEJ). The area was treated using combination Cryotherapy and Endoscopic Mucosal Resection (EMRJ. (Figures 1-3) Pathology of the EMR sample was positive for Adenocarcinoma (Figure 4) A subsequent surveillance ECD showed the previous EMR site, a ...
After implementation of AI decision support, the benign biopsy rate decreased from 71.79% to 59.2% while the overall biopsy rate stayed constant. PPV3 increased from 28.2% to 40.8%. Objective To examine the affect of prospective AI decision support (Koios DS Breast) use on breast ultrasound biopsy performance metrics. Materials and Methods Non-identifiable HIPAA compliant data collected ...
Yale Medicine, an academic medical center with a high volume of prostate biopsies, conducted a study to determine Paige Prostate’s utility as a prescreening tool for clinical use. A total of 1,876 prostate core biopsy slides were analyzed by Paige Prostate, and only those cores categorized by the AI as “suspicious” or as out of distribution were manually reviewed by Yale ...