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Bioreactor Articles & Analysis
21 articles found
Fluoropolymers: A Critical Enabler in Cell and Gene Therapies Cell and gene therapies are revolutionizing medicine, offering cures for rare diseases and innovative treatments for cancer. Behind every successful therapy is a precise and sterile manufacturing process—where the choice of materials can make the difference between success and ...
Key Challenges in Development Despite technological progress, downstream processing development faces persistent hurdles: l Increased upstream productivity: Modern bioreactors yield higher titers, placing pressure on purification steps to handle higher loads of impurities. ...
Infrastructure and Technology Modern CHO cell production facilities are equipped with cutting-edge technology, ensuring high-quality output. These facilities utilize bioreactors with controlled environments that optimize cell growth and antibody production. ...
This characteristic enables the production of large quantities of protein in bioreactors, a crucial aspect for commercial applications. Another significant advantage is the extensive body of knowledge surrounding CHO cell biology and genetics. ...
This often involves the use of bioreactors and optimization of culture conditions to maximize yield while maintaining product quality. ...
The Use of Bioreactors In The Pharmaceutical IndustryThe pharmaceutical industry relies heavily on bioreactors to support a wide range of biological research applications, from cell therapy to vaccine development.1 These bioreactors provide a controlled environment for the growth of microorganisms, such as bacteria, cells, and algae, in order to ...
Biotech cosmetics drastically limit environmental impact and as scientifically altered and tested ingredients, they often perform better on the skin.5In cosmetics, these biotech processes are often carried out in a bioreactor. By utilizing biotechnology, the beauty industry is able to create products that are both safe for the environment and effective for consumers.Bioreactors ...
Importantly, the SARS-Coronavirus (SARS-CoV-2) can be grown in Vero cells to high titers, also in an industrial bioreactor setting. (P. Noel Barrett et al. 2017, DOI:/10.1080/14760584.2017.13574719). ...
ByNuvonis
Vero cells’ significant advantages Adherent Vero cells can be grown on surfaces such as cell culture flasks, cell factories, cell stacks, roller bottles, and on micro carriers in stirred tank bioreactors. The largest commercial bioreactor scale that was established for Vero cells so far was 6,000L. ...
ByNuvonis
In silico simulations and in vitro bioreactor experiments show that the BVP design provides adequate survivability for islets and helps avoid islet hypoxia. ...
Co-founder Ryan Bethencourt is one of the investors behind Sustainable Food Ventures Cultivated Meat Startups Landscape: Enabling Technologies Here’s the full list in alphabetical order: Agulos Biotech (US, 2017, cell culture media) — developing Simulated Platelet Lysate (porcine), a replacement for FBS Back of the Yards Algae Sciences (US, 2018, cell culture media) — algae ...
Capital installation A capital cost of $14M for a facility to produce 100M doses compares favourably with an equivalent capacity, virus-based vaccine facility, which would require an investment of $50-$60M to service 2000-4000L single-use bioreactors. The lower capital outlay of the mRNA facility might seem very attractive for the drive to localised manufacturing, servicing ...
Given the relatively small-scale of these processes, the introduction of single-use technologies has increasingly been adopted by CMOs and producers alike as one of the answers to help streamline production; using single-use bioreactors[vii], mixing bags, prepacked columns, disposable filtration systems, amongst others. ...
For our second platform technology, Sygenus, I have been involved in developing a 3D bioreactor system, which has been quite intriguing to optimise. MSCs require surface attachment to metabolise and grow. ...
This requires the cultivation of bacteria or cell cultures in bioreactors with the addition of oxygen in order to be able to manufacture the components of the vaccine on an industrial ...
We used the new model to analyse comparative production costs for either mAbs or nanobodies, at 15,000L bioreactor working volumes. Existing facilities are assumed to be utilised, so no new infrastructure modelled. ...
When it’s time to move to industrial-scale production, Abec – a supplier of bioreactors and fermenters – employs advanced simulation software from Siemens. Abec, a supplier of bioreactors and fermenters, employs advanced simulation software from Siemens to help its customers scale up biopharmaceutical production. ...
The performance of a novel anaerobic membrane bioreactor (AnMBR) for treating antibiotic solvent wastewater was investigated in the start-up stage. ...
I’m sharing here my photos from that exciting day at Autodesk, so that you can be inspired, too. See if you can spot the bioreactor? As the BioFabricate conference makes plain, biology is becoming a design element. ...
Gaur most recently worked as the Director of Cell and Molecular Biology at MandalMed, Inc. in San Francisco, where she led complex research projects using primary cells and stem cells to create bioreactors and led product development in collaboration with stem cell researchers at Stanford University. ...