Carcinoma Squamous Articles & Analysis
10 articles found
However, Merck's bispecific ADC pipeline M1231 also targets EGFR/MUC1, which is co-expressed in a variety of tumor cells, including non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma (ESCC), head and neck squamous cell carcinoma cell carcinoma, triple-negative breast cancer, and ovarian ...
In NSCLC, high Trop-2 expression was observed in 64% of adenocarcinomas and 75% of squamous cell carcinomas (SqCCs). In addition to its function of regulating normal fetal development, Trop-2 is also an intracellular calcium signal transducer, a key component of cell adhesion in human tissues, and plays an important role in stabilizing epithelial tight junctions. ...
In contrast, CADM1 has also been identified as a potential regulator of cell adhesion and epithelial-mesenchymal transition (EMT), suggesting a role in maintaining epithelial characteristics. CADM1 and Head and Neck Squamous Cell Carcinoma (HNSCC) CADM1 is often downregulated in HNSCC and may function as a tumor suppressor. ...
The full name of TROP2 protein is trophoblast cell surface antigen 2, which is highly expressed in a variety of tumors, such as pancreatic cancer, breast cancer, colon cancer, bladder cancer, oral squamous cell carcinoma and ovarian cancer. On June 7, 2022, sacituzumab govitecan was officially approved in China for the treatment of patients with unresectable ...
Moreover, LFQ is commonly used in biomarker detection of other diseases and tumors, such as Vps35 for Parkinson's disease, SOAT1 for hepatocellular carcinoma, GOT2 for prostate cancer, A1AT for bladder cancer. Stable isotope labeling with amino acids in cell culture (SILAC) Stable isotope labeling with amino acids in cell culture is an in vivo metabolic labeling method, which ...
Methods: We identified 275 patients who underwent surgical resection for pathologic stage I-II lung adenocarcinoma or squamous cell carcinoma from 2009 to 2019 in our institution’s prospective surgical database. ...
To discover novel druggable targets for cancers carrying co-mutations in Ras and p53, we performed arrayed, kinome focused siRNA and oncology drug phenotypic screening utilizing a set of syngeneic Ras mutant squamous cell carcinoma (SCC) cell lines that also carried co-mutations in selected p53 pathway genes. ...
Although PSA is virtually absent in most adult tissues, it is expressed in the progression of several malignancies such as neuroblastoma, breast cancer, laryngeal squamous cell carcinoma, pancreatic cancer, non-small cell lung cancer, and small cell lung cancer. ...
In a study abstract presented at WCLC, Universal Dx and its academic collaborators collected plasma samples from 37 patients with stages l-IV lung cancer, including 11 adenocarcinoma, 10 squamous cell carcinoma, 11 small cell lung cancer (SCLC), and five rare lung cancer subtypes (large cell, carcinoid tumors). ...
The purpose of this case study is to highlight ways in which medical algorithms can be integrated into the clinical decision making process. This case study is the first of a series focused on sepsis, a common but complex clinical problem. Use of algorithms can help healthcare providers diagnose sepsis early. Throughout our discussion, appropriate algorithms are suggested to help clinicians ...