Cardiac Fibrosis Articles & Analysis
5 articles found
Upon intravenous injection in mice with dextran sulfate sodium-induced colitis, this surface-modified LNP actively targeted Ly6c+ white blood cells and induced IL-10 production, significantly suppressing inflammation in the colon. 2) T cell-targeted LNP Cardiac fibrosis is caused by excessive production of extracellular matrix by cardiac ...
Hyperglycemia and insulin resistance can promote autonomic neuropathy, contributing to cardiac stiffness, hypertrophy, and fibrosis. [41] Sex Differences The higher occurrence of HFpEF in women suggests that sex-dependent mechanisms may be involved in HFpEF pathogenesis (Dunlay et al., 2017).[41] In general, women tend to show more concentric LV remodeling, ...
January 6, 2022—Researchers at the Perelman School of Medicine at the University of Pennsylvania published a research paper in Science titled: CAR-T cells produced in vivo to treat cardiac injury. Heart damage or inflammation can induce fibroblasts to overproduce fibrous material, causing cardiac fibrosis, which hardens the heart muscle ...
Preclinical models and biomarkers have identified several likely pathways, apparently involving mitochondrial injury, inflammation, cellular death, and profibrotic. The cardiac consequences of AKI may be mediated by galectin-3 (Gal-3), as shown in studies of mice with AKI in which Gal-3 induced cardiac inflammation, cardiac ...
Elson and Qian to establish a novel mathematical model to understand the development of cardiac fibrosis during heart failure. The model will be used to identify and validate new therapeutic targets to prevent, slow, or reverse cardiac fibrosis. ...