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Cell Biology Articles & Analysis
32 articles found
Significance in Research The creation of SV40-immortalized human ovarian epithelial cells represents a breakthrough for oncology and reproductive biology. These cells provide a consistent and reproducible model for studying various aspects of ovarian biology, including cellular differentiation, hormonal responses, and the ...
This article delves into the significance of recombinant protein expression services specifically utilizing CHO cells, exploring the advantages, methodologies, and applications. The Significance of CHO Cells CHO cells are mammalian cells that originated from the ovary of the Chinese hamster and have been widely adapted for ...
Reporter stable cell lines are invaluable tools in molecular biology and biochemistry. By integrating a reporter gene into the genome of a cell, researchers can create a stable cell line that emits a measurable signal in response to specific stimuli or conditions. ...
The HCEC-12 cell line is known for its ability to proliferate and differentiate, making it a valuable tool for understanding corneal biology. ...
Western BlotThis method can be used to detect and quantify the relative levels of specific collagen in tissue or cell lysates.Molecular Biology Methods1. Quantitative Real-Time Polymerase Chain Reaction (qPCR)By measuring the mRNA level of the collagen gene, the expression level of collagen can be indirectly inferred. ...
In the world of biotechnology and cell biology, the immortalization of primary cells has long been a challenge. Traditional methods often fall short when trying to establish immortal cell lines from certain species, such as chickens, monkeys, dogs, and even human T cells. ...
The centrosome is a key cellular structure that plays a crucial role in the organization of microtubules and regulating the cell cycle. Due to the importance of many proteins localized in centrosomes in cell movement, such as isomorph CRA and HS actin gamma1, antibodies targeting these proteins have also become powerful tools for treating related diseases. ...
Understanding the Cytoskeleton The cytoskeleton consists of three main types of filaments: Microfilaments (Actin Filaments): Involved in muscle contraction, cell movement, and cytokinesis. Intermediate Filaments: Provide structural support and stability, connecting cells through desmosomes and hemidesmosomes. ...
In the fields of cell biology and genetic engineering, gene knockout is a commonly used research method that can help us understand the function and role of a specific gene, and the efficiency of this process is critical. ...
This mechanism is often referred to as a "space-saving" or "economical" process because it allows cells to achieve greater protein diversity using a relatively limited number of genes. ...
Cellular metabolism is the general term for the ordered series of chemical reactions that occur within cells to sustain life. These reactive processes allow organisms to grow and reproduce, maintain their structure, and respond to the external environment. Metabolism is usually divided into two categories: catabolism, which breaks down large molecules for energy (e.g., cellular ...
T cells are the most numerous and functionally complex type of lymphocytes, mainly including CD4+ T cells and CD8+ T2 cells, which play an important role in cellular immunity and assist in humoral immune response. According to their functions in the immune response, T lymphocytes mainly include helper T cells (Th ...
This blog aims to provide insights into apoptosis assays, their methodologies, and their significance in understanding the mechanisms underlying cell death. Understanding Apoptosis Apoptosis is a programmed form of cell death that eliminates damaged or unwanted cells from the body. ...
Evaluating the stress related effects of various restraint methods in rodents Any restraining device used in an inhalation exposure set-up will be, by definition, restricting the subject’s ability to move. For nose-only inhalation set-ups, typical restraints are rigid, fully enclosed and include a metal or acrylic plunger forcing the subject forward and preventing the subject from ...
Stable cell line development is a complex, multi-step process that involves several key stages, including transfection, selection, and screening, and it starts with the careful modification of host cells. ...
Harnessing the power of cell biology, scientists across the globe are perpetually invested in the pursuit of understanding the complexities of cellular mechanisms and their adaptability. ...
The Role of CD19-Complex in B Cell Activation The CD19-complex, also known as the B cell co-receptor complex, is a group of cell surface proteins that play a critical role in B cell activation and signaling. ...
In many cases, gene therapy requires a vector to deliver the gene therapy drug to the target cell. Viral vectors have been one of the most widely studied vectors due to their outstanding transduction efficiency and other significant advantages. ...
Introduction of Diabetes Diabetes is a serious chronic disease characterized by elevated blood sugar concentrations associated with the effects of abnormal beta cell biology on insulin action. Diabetes occurs when the pancreas does not produce enough insulin or the body does not use the insulin it does produce efficiently. ...
IL-36 is mainly distributed in skin, lungs, joints, intestines, kidneys, and the brain, and can be produced by various cells such as monocytes/macrophages, T lymphocytes, B lymphocytes, keratinocytes, M2 cells, Langerhans cells, etc. ...