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Cell Therapy Articles & Analysis
137 articles found
CAR-T cell therapy has transformed the treatment landscape for hematological cancers, yet its widespread adoption remains limited by the complexity of ex vivo manufacturing. ...
Fluoropolymers: A Critical Enabler in Cell and Gene Therapies Cell and gene therapies are revolutionizing medicine, offering cures for rare diseases and innovative treatments for cancer. Behind every successful therapy is a precise and sterile manufacturing process—where the choice of materials can make ...
l Complex product formats: Bispecific antibodies, antibody-drug conjugates, and fusion proteins introduce unique purification challenges. l Gene and cell therapies: Large biomolecules like adeno-associated virus (AAV) or lentiviral vectors are difficult to purify at scale. ...
Among various delivery systems, lentiviruses have garnered significant attention due to their ability to introduce genetic material into both dividing and non-dividing cells, making them an ideal vehicle for gene therapy applications. Understanding CRISPR/Cas9 Technology CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) coupled with Cas9 ...
The BCL2 gene, short for B-cell lymphoma 2, is a critical regulator of apoptosis, or programmed cell death. ...
By administering recombinant chemokines, scientists can redirect immune cells to the tumor microenvironment, potentially enhancing the efficacy of checkpoint inhibitors or CAR-T cell therapies. ...
Cancer treatment has witnessed transformative advancements over the past few decades, notably with the emergence of CAR-T (Chimeric Antigen Receptor T-cell) therapy. This revolutionary therapy harnesses the body's immune system by genetically engineering T-cells to target and destroy cancer cells. Among the ...
They work by binding to foreign molecules, known as antigens, which can be proteins, polysaccharides, or other substances found on pathogens or abnormal cells. By binding to these antigens, antibodies can neutralize pathogens directly or mark them for destruction by other immune cells. ...
Podocytes are specialized epithelial cells located in the kidneys, playing a crucial role in the filtration barrier of the glomerulus. These unique cells have garnered significant attention in scientific research due to their pivotal function in maintaining kidney health and their involvement in various kidney diseases. ...
Unlocking the Power of Organoids Organoids are three-dimensional structures that replicate the functions of actual organs within the body. They develop from progenitor cells, which researchers obtain either from embryonic tissues or pluripotent stem cells (PSCs). ...
Alfa Cytology employs state-of-the-art techniques including isolation, culture, engineering, expansion, and characterization of immune cells and stem cells to develop novel cell therapies. These innovative solutions are grounded in a comprehensive understanding of tumor biology and immune system dynamics, empowering researchers ...
Both concepts encapsulate the complexity of cellular processes and open new avenues for targeted therapies. What is Synthetic Lethality? Synthetic lethality occurs when the simultaneous disruption of two genes leads to cell death, whereas the disruption of either gene alone does not affect cell survival. ...
By harnessing the natural capabilities of the immune system, immuno-oncology services are revolutionizing the way we approach cancer treatment, offering novel therapies that are changing the prognosis for many patients. Understanding Immuno-Oncology Immuno-oncology focuses on the interaction between the immune system and cancer cells. ...
By creating cell lines with specific genes “knocked out,” scientists can investigate disease mechanisms, screen drug candidates, and develop gene therapies more effectively. This article explores the significance, methodologies, applications, and future prospects of custom knockout cell lines. Understanding Knockout ...
These findings could improve our understanding of neurological disorders such as autism and epilepsy. 3. Protein Mapping in Cell Cycle Phases A 2024 study mapped out thousands of proteins involved in cell division, providing a molecular blueprint for developing more targeted cancer therapies. Implications for Cancer Treatment Since ...
This initiative signifies a major leap forward in the development of more effective cancer therapies, aiming to boost both precision and versatility within treatment paradigms. As cancer treatment methodologies continue to evolve, there is an escalating demand for innovative and personalized approaches. Traditional therapies often lack the specificity needed to ...
Among the various forms of immunotherapy, CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) has shown promise, particularly in treating acute lymphoblastic leukemia (ALL), especially in children and young adults. This therapy involves genetically modifying a patient’s T-cells to ...
These technologies allow scientists to cut, insert, or modify specific DNA sequences, enabling the customization of T cells to recognize and attack disease-specific antigens. Applications in Cancer Therapy One of the most promising applications of gene editing in primary T cells is in cancer therapy. ...
They are synthesized and secreted by a range of immune cells, including monocytes, macrophages, T cells, B cells, and natural killer (NK) cells, as well as certain non-immune cells like endothelial cells, epidermal cells, and fibroblasts. Cytokines are produced in response to ...
Human umbilical cord cells, particularly those found in Wharton’s jelly, have emerged as a focal point in regenerative medicine and cellular therapy. ...