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Cells For Potential Therapeutic Articles & Analysis
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Drug Delivery Systems Beyond their role in vaccination, VLPs also hold potential as drug delivery systems. Their nanoscale size, biocompatibility, and ability to encapsulate therapeutic agents make them suitable carriers for both small molecules and larger biomolecules like proteins and nucleic acids. VLPs can improve the bioavailability and stability of drugs ...
Knockin cell line generation represents a pivotal advancement in genetic engineering, providing vital tools for biological research and therapeutic development. ...
HCP (Host Cell Proteins) residual detection is a key quality control step in the field of biopharmaceuticals, aiming at ensuring that the proteins of the host cells used for producing therapeutic proteins in any cell-based production system are maintained at acceptable low levels in the final drug product.ImportanceHCPs are ...
Nanobodies can be engineered to specifically target tissues or cells of interest by conjugating them to therapeutic agents. This targeting ability minimizes off-target effects and increases the efficacy of the drug. For example, nanobodies have been successfully used to deliver chemotherapeutic agents to tumor cells, resulting in improved cancer ...
Alfa Cytology has announced tumor models customization service for pancreatic cancer research. Alfa Cytology, a biotech company specializing in cancer research, has recently unveiled the service on pancreatic cancer tumor model customization to dig into the generation and development of pancreatic cancer and correspondingly provides customized plans for study. Pancreatic cancer is one kind of ...
AAV vectors are used as delivery vehicles or "vectors" to administer therapeutic genes into patient's cells. This therapeutic gene, once inside the cell, generates a functional protein to correct or counter the effects of the disease-causing genetic mutation, providing a basis for curing several genetic diseases. ...
With the approval of many antibody-drug conjugation (ADC) drugs around the world since 2019, conjugate drugs have developed into one of the hottest tracks in the pharmaceutical industry. Not only the research and development of traditional ADCs continues to be hot, but various new drug conjugates (NDCs) are also blooming. In this article, we make statistics on the research and development ...
Coupling drugs combine the precise targeting and potent killing properties, has become a widely recognized form of medication in recent years. Radioactive drug conjugates (RDCs), as a particular form of coupling drugs, are formed by combining radioactive isotopes with disease-targeting molecules. According to the application of RDCs, they can be divided into two main categories: diagnostic RDCs ...
In the vibrant realm of cellular biology and regenerative medicine, mesenchymal stem cells (MSCs) hold unparalleled potential for therapeutic applications. ...
Microneedles (MN) is a new type of physical permeability-enhancing technology. It consists of multiple micron-scale fine needle tips connected to the base in an array. The needle body is generally 10-2000 microns high and 10-50 microns wide. The length, size and shape of the microneedles can be individually designed according to the needs of the application. When the microneedle delivers the ...
What is Hydrogel? Hydrogels are a class of widely studied and applied biomaterials. Hydrogels have been widely studied as cell scaffolds and drug delivery vehicles because their chemical and physical properties are very close to the natural environment of cells. Hydrogels can encapsulate both cells and biomolecules, and many gel systems can closely control the release properties through ...
Furthermore, pilot implantations in pigs were performed, which demonstrated the scalability of the technology. Given the potential benefits provided by the BVP, this tissue design may eventually serve as a solution for transplantation of pancreatic islets to treat or cure type 1 diabetes. Keywords Tissue engineering, Islet transplantation, Type 1 diabetes, Vascular graft, ...
Over time, genetic research have recognized a number of genetic danger variants related to neurodegenerative problems and helped reveal new organic pathways and genes of curiosity. Nevertheless, genetic danger variants generally reside in non-coding areas and should regulate distant genes reasonably than the closest gene, in addition to a gene’s interplay companions in organic networks. ...
Exosomes are nanoscale particles that can be secreted into the extracellular space or body fluids by almost all cell types, with a diameter of approximately 30–200 nm. As a natural intercellular substance carrier, they achieve intercellular communication through the transfer and transmission of biomolecules and have been used as natural delivery carriers for drug molecules ...
They can be used as stand-alone treatments or can be used as starting materials required for further processing of cell and gene therapeutics. When used as starting materials, they have been shown to have a significant impact on the cost of final cell and gene therapy products. ...
The Engineered Micro Pancreas from Betalin Therapeutics is heading closer to clinical trials in humans. Ahead of International Diabetes Day, November 14, Israeli startup Betalin Therapeutics announced that it is beginning the application process for clinical trials of its revolutionary artificial pancreas. Betalin’s Engineered Micro Pancreas (EMP) aims to free patients suffering from the ...
One major challenge for implementing stem cell treatment in the clinics, is the interdisciplinary work required by stem cell biologists and medical doctors as well as the state-of-the-art equipment needed at public hospitals to successfully translate the basic stem cell knowledge into clinical products. Our facility directly serves to speed up the development cell therapeutics, by establishing an ...
ByBaker
Abstract Viral infection of the liver is a major risk factor for hepatocellular carcinoma (HCC). Natural killer (NK) cells recognize virally infected and oncogenically transformed cells, suggesting a therapeutic role for NK-cell infusions in HCC. Using the K562-mb15-41BBL cell line as a stimulus, we obtained large numbers of activated NK cells from the peripheral blood of healthy donors. ...
Nanoparticles as drug vehicles potentially improve the pharmacokinetic and pharmacodynamic properties of various types of drugs, and provide a tool to visualise molecules and tumour target cells that otherwise cannot be detected through conventional imaging. However, there are many aspects of nanoparticle formulation, characterisation and their effect on delivery ...
Stem cell research holds promise for applications in regenerative medicine. However many questions remain. For example, will it be possible to patent therapeutic products in this area? Will the necessary investment be forthcoming? In addition there are still many technical problems to be solved. Technical solutions may involve the use of human embryos and this has created barriers to the use of ...