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Clinical Laboratory Articles & Analysis
41 articles found
Challenges and Future Prospects While lipid nanodiscs hold great promise, they still have some way to go before clinical application: Stability Issues: Long-term storage or excessive drug loading may lead to morphological changes. ...
Understanding CAR-T Therapy CAR-T therapy involves extracting T-cells from a patient's blood, modifying them in a laboratory to express specific receptors that can recognize cancer cells, and infusing them back into the patient. ...
The quest for effective therapeutics begins long before a drug reaches clinical trials. One of the cornerstones of this process is drug screening in animal models, which plays a pivotal role in evaluating the safety and efficacy of potential treatments. Animal models offer researchers valuable insights that cannot be obtained through in vitro studies alone, bridging the gap ...
Its offerings encompass comprehensive support in drug discovery, preclinical trial design, and strategic planning for translating laboratory findings into effective clinical ...
By modeling and simulating these interactions, scientists can predict the behavior of a drug across various populations and dosing scenarios. This aids in designing clinical trials, personalizing medicine, and improving drug safety profiles. ...
Building innovative solutions to common laboratory challenges has been Advanced Instruments’ mission since 1955, a time when electronic automation was just beginning to be applied to laboratory methods. Throughout its 70-year history, Advanced Instruments’ osmometers have helped global clinical laboratories ...
In recent years, the landscape of sequencing technologies has undergone a transformative shift, transitioning from research settings to the realm of clinical laboratories. This transformation has been catalyzed by rapid technological advancements and significant cost reductions. ...
POCT (Point-of-Care Testing) refers to clinical and bedside testing conducted in close proximity to patients. It is often not performed by clinical laboratory personnel. POCT holds significant importance in disease prevention, etiology determination, prognosis, enhancing treatment outcomes, and reducing healthcare expenses. It meets ...
Methods: Anti-modified albumin autoantibodies, predominantly ACA, were quantitated using a rapid point-of-care test and the data analyzed by ACA and CCP status for correlations with clinical and laboratory parameters and medication. Results: In two cohorts of RA patients (n=168), 55% were positive for anti-modified albumin autoantibodies (here referred to as ...
The Development Trend of PROTAC Verify the degradation of "non-druggable proteins" in clinical trials: At present, PROTAC molecules that have entered the clinical trial stage mainly target traditional AR, ER, BTK, etc. ...
Current diagnostic algorithms include clinical, laboratory, and instrumental characteristics; sophisticated imaging modalities; and invasive measurements. ...
Physical signs of heart failure (HF) (such as elevated jugular venous pressure, pulmonary rales, and lower extremity edema) may or may not be present. [9] A history of atrial fibrillation (AF), obesity, and diabetes all increase the likelihood of HFpEF. [10] (Table 1). Table 1. Clinical, laboratory and imaging predictors of HFpEF.[11] Some patients with HFpEF ...
About the Study: A study was performed to demonstrate the accuracy of the Embrace No Code Blood Glucose Management System (Embrace) compared to a clinical laboratory reference method (YSI-2300). Healthcare professionals performed the evaluation with 158 patients either with or without diabetes. ...
In addition, process development from laboratory scale to clinical scale can be provided, as well as quality control and stability testing. ...
The Holiday season often brings mixed feelings for many. While it can be a time of relaxation with friends and family for some, for others, preparing for this time means ensuring business continuity despite a typical slow down. This can be a source of undue stress if it is not suitably planned for. ...
We also discuss challenges posed in clinical trial design for these novel device–based strategies including optimal patient selection and appropriate end points to establish efficacy. ...
“Nicoya’s Alto SPR instrument has the potential to be approved as an IVD device for the delivery of such clinical diagnostics in pathology laboratories worldwide.” The parties have made an intention to enter into a commercial arrangement enabling INOVIQ to commercialise the SubB2M-based SPR test if successful. ...
Whereas their interests encompass basic research, pathology, tissue response mechanisms and clinical application, their collective knowledge covers the entire field of Low Intensity Laser Therapy. ...
This is critical for many types of medicines, vaccines, reagents, and biological samples, which is the reason why laboratories, hospitals, clinics, pharmacies, and more employ medical-grade refrigerators to protect their samples from ambient ...
The comprehensive cancer center designation means patients can access treatments exclusive to Karmanos, as well as clinical trials, cancer prevention programs, and multidisciplinary teams of cancer specialists — a comprehensive approach you cannot find in many large hospitals or health systems. ...