Collagen Deposition Articles & Analysis
5 articles found
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While ...
With the rapid development of science and technology, the raw materials used in electrospinning tend to be diversified, such as natural polymers and synthetic polymers. Recombinant human collagen, a natural biosynthetic material with good biocompatibility, low immunogenicity, degradability and absorbability, has been widely used in hemostasis, wound healing, drug slow-release ...
Analysis of tissue staining and immunohistochemistry showed that the natural hydrogel significantly accelerated the granulation tissue regeneration, angiogenesis and collagen deposition in chronic wounds, and significantly down-regulate the expression levels of TNF-α, IFN-γ, IL-6 and other inflammatory cytokines in tissues. ...
The isolated cells were characterized with respect to viability, growth kinetics, cytokine production, and phenotype. 3D bioprinted liver tissue was generated using either NPCs isolated from diseased donors combined with non-diseased hepatocytes, or hepatocytes isolated from diseased donors combined with non-diseased NPCs. 3D bioprinted liver tissue generated using NPCs from a diseased donor ...
The coadministration of galunisertib with TGFβ prevented the characteristic features of TGFβ-induced fibrosis, including upregulation of collagen deposition, phosphorylated SMAD2/3, and TIMP-1. Increased HSC activation was observed only in the TGFβ-induced fibrosis model, demonstrated by α-smooth muscle actin (αSMA) labeling and ...