Cryo Electron Microscope Articles & Analysis
7 articles found
Molecular docking, a critical component of structure-based virtual screening, plays a pivotal role in the field of drug design by predicting the binding interactions between small molecules and proteins. This article explores the various approaches, software tools, and techniques employed in molecular docking and highlights their potential in accelerating drug discovery. The Importance of ...
A team of scientists from around the world, including from Trinity College Dublin, has obtained high-resolution structural insights into a key bacterial enzyme, which may help chemists design new drugs to inhibit it, thereby inhibiting disease-causing bacteria. Their work is important amid growing concerns about rising antibiotic resistance. The scientists, led by Martin Caffrey, Emeritus ...
For the first time, scientists have elucidated the structure of GABA transporter 1 (GAT-1) using cryo-electron microscopy. The discovery could lead to better new treatments for neurological disorders such as anxiety, autism spectrum disorder, schizophrenia and Parkinson's disease. ...
However, her team's search for new treatments for acute myeloid leukemia was hampered by a subtle gap between two techniques used to understand protein structure and function—X-ray crystallography on the one hand, and cryo-electron microscopy (cryo-EM) on the other. Researchers from Stanford University School of Medicine and Engineering ...
Our fifth annual round-up of the tools that look set to shake up science this year. From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead. Fully finished genomes Roughly one-tenth of the human genome remained uncharted when genomics researchers Karen Miga at the University of ...
Australian researchers have recently solved a multi-year mystery about Parkinson's disease. They solved the structure of a key protein that is expected to rapidly treat this incurable disease. The findings appear in Nature. For the first time, the researchers took a "live" shot of a protein called PINK1. The findings explain how this protein is activated in cells, thereby initiating the ...
Abnormal accumulation of misfolded tau in filaments is characteristic of many neurodegenerative diseases—precisely for this reason, these neurodegenerative diseases are collectively referred to as tauopathy. The Michel Goedert team and the Sjors Scheres team at the Molecular Biology Laboratory of the Medical Research Council in Cambridge, UK, witnessed the use of cryo-EM to dissect tau ...