Cytokine Il Articles & Analysis
31 articles found
What Are Cytokines and Chemokines? Cytokines are small proteins secreted by cells that have a profound influence on the behavior of other cells. ...
Additionally, several cytokines are undergoing clinical trials, including interleukins like IL-1, IL-3, IL-4, IL-6, and IL-11, as well as transforming growth factor beta (TGF-β) and macrophage colony-stimulating factor (M-CSF). ...
Th2 cells mediate humoral immune responses by secreting cytokines such as IL-4 and IL6, which promote B-cell differentiation and antibody production. ...
Binding of adjuvants to antigens can increase the surface area of the antigen, and the biological effects include (1) deposit effect of antigen; (2) upregulation of cytokine and chemokine expression, and recruitment of immune cells at the injection site; (3) activation of inflammasome; and (4) carrier effects. ...
Some of the major cytokine families include: Interleukins (ILs): This is the largest and most diverse family of cytokines, encompassing over 30 members. ...
In a mouse model, oral administration of IL-22 mRNA-loaded LNP significantly increased IL-22 expression in the colonic mucosa and accelerated the healing of colitis. ...
The IL-1 superfamily of cytokines includes IL-1α, IL-1β, IL-33, IL-1Ra, IL-18, IL-37, IL-36Ra, IL-36α, IL-36β, IL-36γ, and IL-38, which play important ...
In addition, persistent activation of NF-κB increases the levels of a number of cytokines that promote cancer growth, such as IL-1β (acute leukemia growth factor), TNF (malignant lymphogranuloma, T-cell lymphoma, and glioma growth factor), and IL-6 (growth factor in multiple myeloma). ...
The results showed that the activation of NF-κB was inhibited in the treated mice, and inflammatory cytokines TNF-α, IL-6 and IL-1 showed a decreasing trend, and intestinal inflammation was improved. ...
Cytokine Classification Cytokines are categorized into various subtypes, including interleukins (IL), interferons (IFN), tumor necrosis factor (TNF), colony-stimulating factor (CSF), chemokines, and growth factors (GF). ...
Cytokine Involvement in Rheumatoid Arthritis (RA) RA, an immune-related polyarticular inflammatory disorder, involves a spectrum of cytokines, including IL-1B, IL-6, IL-12, IL-15, and TGF-β. ...
Studies show that IL-17F and IL-17A have a synergistic effect: unlike inhibiting IL-17A alone, inhibiting these two cytokines at the same time can significantly increase the down-regulation of inflammatory mediators in skin and joint fibroblasts. ...
The use of IL-2 alone, or in combination with other cytokines such as TNF-α or IFN-γ, can increase the cytotoxicity of macrophages. ...
N-terminally truncated IL-36α, IL-36β, and IL-36γ are 1000 to 10,000 times more active than the non-truncated cytokines, and the antagonistic activity of IL-36Ra depends on the removal of its N-terminal glutamic acid. ...
TSLP and TSLPR TSLP (Thymic Stromal Lymphopoietin) is a member of the four-helix bundle cytokine family and is a distant homolog of IL-7. As the name suggests, TSLP was initially identified in the mouse thymic stromal cell line Z210R, as a factor that promotes the proliferation and development of immature B cells. ...
Indeed, it has been suggested that the overexpression of cytokines IL-17 and IL-6 by Th17 could contribute to the maintenance of pathogenic inflammatory phenomena and to the production of autoantibodies. ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, ...
More importantly, this new therapy has been validated in mouse solid tumor models of melanoma and pancreatic cancer, providing new strategies for the study and application of adoptive T cells in the treatment of solid tumors. IL-2 is a cytokine required for proliferation, survival, and functional maintenance of effector T cells and is an important therapeutic ...
The results showed that the intestinal inflammation was improved in the treated mice since the activation of NF-κB was inhibited and the inflammatory cytokines TNF-α, IL-6, and IL-1 were reduced. 4. Bactericidal Effect Broad-spectrum antibiotics are difficult to inhibit or kill intracellular bacteria, which cause great harm to ...
Various immune cells in the body such as macrophages, neutrophils, natural killer cells and dendritic cells can release various cytokines, such as IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, chemokines, granulocyte colony-stimulating factor, granulocyte megakaryocyte colony-stimulating ...