Cytokine Receptor Articles & Analysis
9 articles found
Compared with traditional chemotherapy and hematopoietic stem cell transplantation, it is more precise in killing tumor cells and significantly reduces toxic side effects while improving efficacy. Cytokines in CAR-T cell therapy Cytokines are pleiotropic and diverse, and enhancing T-cell activation signaling by transgenic expression of ...
Depending on their composition, this class of molecules includes antibody-based PROTAC (AbTAC/PROTAB), Lysosome-Targeting Chimeras (LYTAC), GlueBody Targeting Chimera (GlueTAC), Cytokine Receptor-Targeting Chimeras (KineTACs), and Signal-Mediated Lysosome-Targeting Chimeras (SignalTACs). ...
In addition, the receptor composed of IL-17RD and IL-17RA has been identified as an alternative receptor for the IL-17A homodimer. ...
Frontiers in cell and developmental biology, 2019, 7:317-317. [2] Melton E , Qiu H . Interleukin-36 Cytokine/Receptor Signaling: A New Target for Tissue Fibrosis[J]. International Journal of Molecular Sciences, 2020, 21(18). [3] MF Neurath. IL-36 in chronic inflammation and cancer[J]. Cytokine & Growth Factor Reviews, 2020, 55. [4] Gresnigt ...
Cytokines-mediated signaling is a primary way of immune system communication. The common gamma-chain family of cytokines is a set of six cytokines that signal through the common cytokine γ chain receptor (γc/CD132/IL2RG). These cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and ...
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. ...
Cytokines function in autocrine, paracrine or endocrine forms, and can regulate cell growth and differentiation, modulate immune response and participate in the development of various diseases such as inflammation by binding to the corresponding receptors. Cytokine storm is also known as cytokine waterfall cascade, or ...
After first understanding the effects on the intestinal epithelium, other cell types, cytokines, and architecture can be added to make the model more complex. ...
While it is well appreciated that receptors for secreted cytokines transmit ligand-induced signals, little is known about additional roles for cytokine receptor components in the control of ligand transport and secretion. Here, we show that interleukin-15 (IL-15) translocation into the endoplasmic reticulum occurs independently ...