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Detect Disease Biomarkers Articles & Analysis
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They constitute an intricate "glycocode" that orchestrates numerous cellular functions from embryonic development to immune regulation and disease progression. N-Glycan Profiling: Beyond the Basics N-Glycan Profiling reveals the remarkable complexity of these structures that anchor to asparagine residues. ...
PEG-modified nanoparticles can be used as biomarkers for detecting and imaging biomolecules. Carboxylic acid PEGs can be combined with markers such as fluorescent dyes or radionuclides to achieve high-resolution imaging and fluorescent labeling in vivo. In addition, carboxylic acid PEGs can be used to construct imaging probes with specific biological activities, ...
The accurate and timely diagnosis of preeclampsia is critical in management of affected pregnancies to reduce maternal and fetal/neonatal morbidity and mortality, yet difficulties remain in establishing the rigorous diagnosis of preeclampsia based on clinical parameters alone. Biomarkers that detect biochemical disease have been proposed as ...
Modern epigenetic features refer to the alteration of DNA and/or associated proteins without nucleotide sequence variance, which transmits the data contained to the next generation. It has been considered that diseases are generally influenced by obtained biological alterations, but it is becoming evident that any phenotype is the result of a complex interplay between genotype, ...
The application of existing WGS technologies to rare disease cases has proven to be useful in identifying the cause of disease by detecting multiple and comprehensive mutations at the whole-genome level, providing invaluable insights into the underlying molecular mechanisms of various rare diseases and opening up new ...
Small RNAs are important functional molecules in organisms, which have three main categories: microRNA (miRNA), small interfering RNA (siRNA), and piwi-interacting RNA (piRNA). They are less than 200 nt in length and are often not translated into proteins. Small RNA generally accomplishes RNA interference (RNAi) by forming the core of an RNA-protein complex (RNA-induced silencing complex, RISC). ...
To understand the significance of the SpinTech MRI STAGE software platform, it helps to begin by asking a question: Given that MRI is an incredibly powerful diagnostic tool for neurological diseases like Alzheimer’s, dementia, Parkinson’s and multiple sclerosis (MS), why have radiologists and neurologists had to choose between conducting faster MRI exams and obtaining ...
The use of Quantitative Susceptibility Mapping (QSM) is often viewed as incompatible with current standard radiology workflows. Some radiologists or departments may be unaware of its existence or purpose. Despite the skepticism surrounding its viability in a clinical setting, QSM shows great potential in a wide range of clinical applications, particularly for biomarker detection and ...
Urine E-cadherin was supposed to be a marker for early detection of kidney injury in diabetic patients. In Sun’s research, label-free quantification was applied to systematically compare the protein profiling in saliva and serum exosomes from healthy subjects and lung cancer patients, and potential candidates were discovered as biomarkers for lung cancer. ...
And the activation of ab initio synthesis is negatively correlated with prognosis and disease-free survival in several tumor types. This phenotype is mainly due to the upregulation of lipogenesis-related genes at multiple levels of transcriptional, translational and post-translational modifications, and enzymatic activity, as well as the impact on oncogene expression due to ...
Pathology AI algorithms can help pathologists diagnose diseases with greater efficiency and accuracy, as well as detect biomarkers that can inform patient treatment at the point of diagnosis. Working toward establishing coding and payment for these downstream procedures as well will allow clinicians and patients to fully reap the benefits of AI ...
Recently, in a study published in the journal Scientific Reports entitled "Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis", scientists from Washington State University found through the study that cells from cheek wipes may reveal biomarkers of rheumatoid arthritis, which may help develop a ...
Digital biomarkers including breathing rate are calculated from 24/7 monitoring of subjects in home environments. ...
Abstract Purpose: We evaluated Galectin-3 (Gal-3) as a potential early biomarker of acute kidney disease (AKI), and the effect of Gal-3 inhibition by modified citrus pectin (P-MCP) on renal ischemia/reperfusion (I/R) induced AKI. ...
SEVILLE, Spain--(BUSINESS WIRE)--Universal Diagnostics (UDX), an in-vitro diagnostics company developing minimally-invasive, blood-based solutions for detecting cancer early, announced today that it has started a prospective, multi-center observational study in the US for its investigational advanced adenoma (precursor lesions) and colorectal cancer (CRC) detection blood test. UDX is performing ...
NEW YORK - Spanish cancer research firm Universal Diagnostics is gearing up to commercialize a liquid biopsy test that applies methylation biomarkers to detect lung cancer, based on data presented at the International Association for the Study of Lung Cancer 2020 World Conference for Lung Cancer (WCLC) last month. The Seville-based firm also expects to release clinical data on its next ...
Abstract Purpose: SelectMDx (MDxHealth®) is a panel of urinary biomarkers used in conjunction with traditional risk factors to individualize risk prediction for clinically significant prostate cancer. In this study we sought to characterize the effectiveness of SelectMDx in a population of American men with elevated prostate specific antigen. Materials and methods: We developed a ...
Among biosensors of various types, the silicon nanowire field–effect transistor (SiNW–FET) is believed to be the most sensitive and powerful device for bio–applications. In fact, these devices have demonstrated the ability to detect a variety of analyses such as particular DNA sequences, cancer biomarkers and larger entities such as viruses. The principle of sensing is based on the variation of ...
Although intersex of fish species has been widely reported in aquatic environments, there is no appropriate biomarker of the effects to assess the occurrence of intersex. In the present study, mRNA expression profiles of 14 genes, which are either involved in ovary development and maintenance or have relatively high mRNA transcription levels in ovarian gene expression profiles in fish species, ...
Organic contaminants are continually entering aquatic environments and thence the tissues of resident biota. Mussels and other molluscs are used worldwide as sentinels in pollution monitoring. Recent years have seen the development of biological measurements (biomarkers) as tools for use in monitoring and environmental impact assessment, such biomarkers being indicative of contaminant exposure ...