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Disease Detection And Recurrence Articles & Analysis
9 articles found
This white paper details a study by Predictive Oncology and UPMC Magee-Womens Hospital. By combining the assets and domain expertise of both organizations, this collaboration aimed to improve ovarian cancer prognosis and treatment through accurate patient stratification and survival outcome predictions. Background and objective High grade serous carcinoma (HGSC) of the ovary is a complex and ...
Patient History A 68 year old male being treated for short segment (1cm) Barrett's Esophagus (BE). During a prior exam, combination therapy for recurring non-dysplastic BE by Endoscopic Mucosal Resection (EMR) and Radiofrequency Ablation (RFA) was conducted. The intent for this procedure was to assess the treatment area, in part, using the NvisionVLE Imaging System, and to ablate any recurrence ...
Some patients with multiple myeloma often relapse due to the emergence of immune escape mutations, which makes cancer cells in the body resistant to therapy; therefore, researchers urgently need a new target antigen to develop a multi-targeted method, so as to avoid immune escape and avoid disease recurrence. In previous studies, researchers focused on ...
Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalcitonin superfamily that plays a dual role in prostaglandin metabolism and lipid transport. PTGDS is involved in various cellular processes including solid tumorigenesis, but its role in tumorigenesis is paradoxical, and the significance of PTGDS in hematologic malignancies is not clear. The aim of this new study was to ...
Radiation therapy choices vary for comprehensive breast cancer treatment. One such option, intraoperative radiation therapy (IORT) is employed in many centers around the country. IORT using the Zeiss® Intrabeam® System has been proven to be non-inferior to External Beam Radiation Therapy (EBRT) in local recurrence and disease-free survival. IORT’s advantage is one treatment during ...
Abstract Background Although herpes simplex viruses (HSV) are a major target for vaccine development no vaccine is currently licensed. Methods A live attenuated HSV virus vaccine, VC2 was compared to a subunit HSV vaccine, glycoprotein D (gD2) administered with the adjuvant, MPL/Alum using the guinea pig model of genital herpes. Three doses of intramuscular (IM) vaccine were provided followed by ...
The cornea is essential for vision yet highly sensitive to immune-mediated damage following infection. Generating vaccines that provide sterile immunity against ocular surface pathogens without evoking vision loss is therefore clinically challenging. Here, we tested a prophylactic live-attenuated vaccine against herpes simplex virus type 1 (HSV-1), a widespread human pathogen that can cause ...
ABSTRACT Background: Although development of an HSV vaccine is a priority there is currently no vaccine available. The recent failure of subunit vaccines suggest that presentation of more antigens via a live attenuated vaccine may be required for protection. We therefore evaluated VC2. a live attenuated HSV vaccine, engineered to be unable to enter into neuronal axons. Methods: VC2 pathogenesis ...
Cancer therapy should aim to prevent recurrent disease. Surgery and toxic treatments remove only symptoms associated with cancer without trying to intervene in the aetiology, therefore the disease may recur. The autologous cancer vaccine supplemented with bio-modulation might fulfil requirements for effective tumour therapy. The autologous tumour vaccine is formed in the same way as our bodily ...