Disease Identification Articles & Analysis
15 articles found
Pathologists and researchers utilize these blocks to conduct histological studies, enabling the identification of kidney diseases, such as glomerulonephritis and diabetic nephropathy. By examining tissue sections under a microscope, scientists can assess changes in kidney morphology and cellular composition, leading to a better understanding of ...
They are increasingly employed in non-invasive techniques to improve the identification and treatment planning of various medical conditions. Contribution to Disease Identification Medical rings play a crucial role in accurately mapping internal organs and structures during diagnostic evaluations, thereby enhancing the precision of ...
These advancements not only enhance our understanding of the disease but also pave the way for more targeted therapeutic solutions. ...
Tau protein is a microtubule-associated protein, mainly present in nerve cells, and participates in the stabilization of microtubules. In certain neurodegenerative diseases, such as Alzheimer's disease (AD), Tau protein may undergo abnormal phosphorylation and aggregation, forming so-called Tau tangles or neurofibrillary tangles.Ubiquitination is a kind of ...
In post-translational modification (PTM) of proteins, ubiquitination is considered one of the most critical processes in regulating cellular functions and various diseases. The identification of ubiquitination sites becomes very crucial for understanding the mechanisms of ubiquitination-related biological processes. ...
The future of antibody-drug conjugate development appears to be very promising, with prospective improvements and advancements in multiple areas: Improved target selection: With the advancement in genomics and proteomics, the future may bring a better understanding of disease biology, leading to the identification of more disease-specific ...
Depending on the focus of the study, lipidomics can be applied to the following pharmaceutical research. Identification of disease biomarkers The most fundamental application of lipidomics in pharmaceutical research is the identification of lipid biomarkers that are associated with lesions in organisms or are expressed abnormally in ...
Rare diseases, also known as orphan diseases, affect a small percentage of the population, making them particularly challenging to diagnose and treat. ...
Alongside the drug-target relationship, the analysis of the drug-disease relationship is equally important. This encompasses the understanding of how a drug's mechanism of action aligns with the underlying pathophysiology of a particular disease. ...
When studying gene expression, researchers often compare gene expression profiles between different biological samples or experimental conditions, such as healthy and diseased tissues, treated and untreated cells, or different developmental stages. ...
In recent years, scientific advances in viral vector engineering, rare disease genome identification, and gene editing are ushering in a new era of viral gene therapy. ...
• Differential gene expression One important way RNA-seq is used is to compare transcriptomes from different stages of development, treatments, or disease states.This analysis, also known as differential gene expression analysis, requires the identification of genes along with their isoforms and a precise assessment of their expression levels. ...
Linkage analysis in family members is a traditional strategy of identification of disease-associated mutation. However, many diseases are rare, which poses challenges for linkage analysis in which data collections from large families are needed. ...
Patient History This patient was a 68 year old man referred with short segment Barrett's Esophagus (BE) with intramucosal carcinoma (IMC). At the referring center, previous resection of nodularity revealed Tla adenocarcinoma with negative margins. Subsequent surveillance biopsies yielded IMC, and triggered referral. For the procedures described here, standard endoscopy with the addition of ...
Maintaining the integrity of biomarkers during their processing and storage is therefore of critical importance to accurately diagnose and give prognosis of many different diseases, including cancers. To safely store samples for research or clinical use, freezing procedures are used to arrest the degradation of biomarkers used for the identification of these ...