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4 articles found

Harnessing the Power of CRISPRa Stable Cell Lines for Enhanced Gene Expression

Harnessing the Power of CRISPRa Stable Cell Lines for Enhanced Gene Expression

In recent years, CRISPR activation (CRISPRa) has emerged as a powerful tool for upregulating gene expression, offering researchers a new way to investigate gene function and potentially develop novel therapeutic strategies. ...

ByCreative Biogene


Nanopore Sequencing: Bioinformatics Analysis of ONT Data

Nanopore Sequencing: Bioinformatics Analysis of ONT Data

In this section, we explore the methodologies and tools developed for the detection of DNA and RNA modifications using ONT sequencing data. ...

ByCD Genomics


Epigenomics: Opening the Black Box of Cancer

Epigenomics: Opening the Black Box of Cancer

They allow researchers to understand how the epigenome contributes to disease development by mapping and comparing the epigenomes of various types of cells or tissues. The basic tools for analyzing DNA methylation are DNA digestion assays and bisulfite sequencing. Unmethylated DNA is cleaved by methylation-sensitive nucleic ...

ByCD Genomics


Mitochondrial DNA variation in the European lobster ( Homarus gammarus) throughout the range

Mitochondrial DNA variation in the European lobster ( Homarus gammarus) throughout the range

The genetic differentiation of the European lobster (Homarus gammarus) was investigated in 3,283 individuals from 44 population samples throughout its geographical distribution (Norway to Greece) by means of polymerase chain reaction restriction fragment length polymorphism analysis of a 3-kb mitochondrial DNA segment. Ninety composite haplotypes were revealed with the number of ...

BySpringer-Verlag GmbH

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