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Drug Action Mechanism Research Articles & Analysis
119 articles found
In the pharmaceutical industry, excipients play a crucial role in the formulation of medicines. These inactive substances, which are combined with the active pharmaceutical ingredient (API), perform various functions that enhance the effectiveness, stability, and overall performance of drug products. Understanding the common types of excipients is essential for pharmaceutical scientists and ...
Lipid synthesis is an integral process within biochemistry that contributes to a myriad of biological functions, including energy storage, cell membrane formation, and signaling pathways. As researchers delve deeper into the complexities of lipid biology, the demand for precise and efficient lipid synthesis techniques has become increasingly evident. This article explores the various methods ...
Kinase screening services assist researchers in identifying active inhibitors, understanding kinase biology, and providing insights into the mechanisms of action of drug candidates. ...
In recent years, the field of antibody drug design has become increasingly significant in the realm of therapeutic development, driven by the need for more effective and targeted treatments for various diseases, including cancer, autoimmune disorders, and infectious diseases. Antibodies, which are proteins produced by the immune system, have the ability to specifically recognize and bind to ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. This assay utilizes Madin-Darby Canine Kidney (MDCK) cells, which are a widely used model for studying intestinal absorption and permeability due to their similarity to human epithelial cells. Importance of the MDCK ...
Introduction to Bioglass Bioglass, also known as bioactive glass, is a type of synthetic material that has revolutionized the fields of medicine and dentistry. First developed in the late 1960s by Dr. Larry Hench and his team at the University of Florida, Bioglass is a glass-ceramic material that has the unique ability to bond with living tissue. This property, known as bioactivity, makes it an ...
ByMatexcel
Alfa Cytology unveils advanced PD-1 inhibitor development service for cancer research. Alfa Cytology, a prominent service provider in the oncology landscape, has recently launched its innovative PD-1 inhibitor development services. This initiative marks a significant advancement in the quest for more effective cancer therapies, focusing on enhancing precision and adaptability in treatment ...
The quest for effective therapeutics begins long before a drug reaches clinical trials. One of the cornerstones of this process is drug screening in animal models, which plays a pivotal role in evaluating the safety and efficacy of potential treatments. Animal models offer researchers valuable insights that cannot be obtained through in vitro studies alone, bridging the gap between laboratory ...
Nuclear receptors are a class of proteins that play a vital role in cellular communication, gene expression, and overall homeostasis within the body. They act as transcription factors, responding to various stimuli, including hormones, nutrients, and even environmental agents. Due to their crucial roles in physiological and pathological processes, nuclear receptors have emerged as significant ...
Colorectal cancer is one of the leading causes of cancer-related deaths globally. To advance our understanding of this disease and improve treatment strategies, researchers heavily rely on colorectal cancer cell lines. These cell lines serve as essential models for studying the biology of colorectal cancer, testing new therapies, and exploring the mechanisms of drug resistance. What are ...
Pharmacodynamics: The Drug’s Effect on the Body Pharmacodynamics examines the biological and physiological effects of drugs and their mechanisms of action. It focuses on the relationship between drug concentration at the site of action and the resulting therapeutic or toxic response. ...
Alfa Cytology has unveiled new services focused on therapeutic antibody development for bladder cancer research.Alfa Cytology, a prominent cancer research services supplier based in New York, proudly announces the launch of its comprehensive services for bladder cancer therapeutic antibody development. This initiative represents a critical advancement in pursuing effective bladder cancer ...
Obesity is a significant contributor to respiratory disorders such as Obesity Hypoventilation Syndrome (OHS) and sleep apnea, both of which are characterized by reduced respiratory chemosensitivity. These conditions not only impair breathing but also exacerbate the health risks associated with obesity. Recent research from Rivera (2024) investigates the potential of setmelanotide, a ...
In vitro permeability assay kits play a crucial role in the field of pharmaceutical development, particularly when evaluating the absorption characteristics of drugs. These kits allow scientists and researchers to investigate how compounds permeate biological membranes, which is vital for understanding drug bioavailability. Understanding Permeability Permeability refers to the ability of a ...
Human corneal epithelial cells play a vital role in maintaining the health and function of the cornea, the transparent front part of the eye. This layer of cells acts as a protective barrier against environmental insults, pathogens, and mechanical injury. Given their crucial functions, understanding these cells is essential for advancements in ophthalmology and regenerative medicine. The corneal ...
In the ever-evolving world of pharmaceutical development, the quest to innovate and improve the delivery of drug substances remains a top priority. Among the many formulation strategies, oral liquid formulations hold a special place, offering alternatives particularly appealing for specific populations and addressing unique formulation challenges. The Necessity of Oral Liquid Formulations ...
Alfa Cytology has introduced its advanced drug development services for brain tumors. Alfa Cytology, celebrated for its cutting-edge biotech solutions and extensive tumor research expertise, has recently introduced brain tumor drug development services, designed to empower researchers in understanding the intricacies and unique challenges associated with brain tumors. Brain tumors represent a ...
Recombinant protein vaccines are vaccines produced using genetic engineering technology. The principle is to clone one or several antigen genes of a pathogen into host cells, causing them to express the corresponding antigen protein. These proteins are then extracted for use in the vaccine. These vaccines can effectively stimulate the immune system to respond to specific pathogens, thereby ...
Peptide drugs are bioactive protein fragments composed of short chains of amino acids. Due to their high efficiency, specificity, and relatively low toxicity and immunogenicity, they occupy an important position in modern medicine and drug development. They have shown great potential in treating various diseases, such as cancer, autoimmune diseases, infectious diseases, and metabolic disorders. ...
GMP growth factors and cytokines designed for therapeutic manufacturing are an essential component of defined media. To date, the cell therapy industry has accepted GMP terms for this reagent class, despite the fact that there is no direct oversight by regulators. These proteins are intended for use in further manufacturing processes and do not come into direct contact with patients. In fact, ...