Drug Exposure Articles & Analysis
15 articles found
Idiopathic pulmonary fibrosis (IPF) is a devasting lung disease characterized by progressive scarring of lung tissue. As fibrosis develops, patients experience worsening shortness of breath, reduced lung capacity and ultimately respiratory failure. Current therapies for IPF rely on oral administration of pirfenidone and nintedanib, two FDA-approved drugs that slow disease progression. While ...
This characteristic makes them ideal for use in drug formulations that require prolonged exposure in the body. 2. Drug Loading CapacityAnother vital metric is the drug loading capacity of the copolymers. PLGA copolymers are known for their high drug loading capacity, accommodating both hydrophilic and hydrophobic ...
However, they substantially concentrate on the potential adverse effects of chemical exposure. Pharmacokinetic studies serve as the foundation for understanding the drug's bioavailability – the degree and rate at which an administered drug reaches the systemic circulation. ...
Light Stability Analysis Light stability analysis is another important technique used in stability analysis to study the effect of light exposure on the stability of a drug. Light can cause the degradation of certain drugs, leading to a decrease in their potency and safety. By studying the impact of light on the stability of a ...
Conventional liposomes As a drug delivery system, traditional liposomes can change the pharmacokinetic properties and tissue distribution of tumor drugs, enhance the target aggregation concentration of drugs, and enhance drug efficacy. ...
Therefore, for the development of Fc-Fusion-related drugs, it is necessary to gain insight into the impact of glycosylation on product quality through various characterization techniques and to closely control the glycosylation of the target product to ensure proper safety and efficacy. ...
This new approach to treatment incorporates patient perspectives into drug development. A key benefit is the keener focus on convenience and safe drug administration. ...
Epigenetics is an emerging field of research that focuses on the effects of environmental factors, such as infections, pollutants, stress, and long-term drug exposure, on an individual's genome. Epigenetic changes do not alter the structure of DNA, but do alter the way DNA is modified. ...
Drug development platform, BIOiSIM™, was used to narrow down two different drug classes with distinct modes of action and modalities. ...
Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. ...
This leads to more extended stays in hospitals and continued exposure to tests, drugs, and potentially to severe hospital-acquired conditions, all while the actual reason for admission remains unaddressed. ...
The Drug Supply Chain Security Act (DSCSA) is Title II of the Drug Quality and Security Act (DQSA), which was enacted to enhance FDA’s ability to protect consumers from exposure to potentially harmful drugs. The act outlines steps to build an electronic, interoperable system to identify and trace certain prescription ...
An estimated 5% of expectant mothers use illicit drugs during pregnancy. Drug use during pregnancy is associated with premature birth, low birth weight and cognitive or behavioral problems for the child. ...
The aim of the present study was to investigate the lethal and sublethal effects of prednisolone (PDS) exposure on the embryonic and post‐hatching stage of the freshwater snail, Physa acuta. ...
Title II of DQSA, the Drug Supply Chain Security Act (DSCSA) focused on building “an electronic, interoperable system to identify and trace certain prescription drugs.” Encompassing every link in the supply chain – manufacturers, repackagers, wholesale distributors, and dispensers, as well as third-party logistics providers – the ...