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Drug Production Articles & Analysis
86 articles found
These inactive substances, which are combined with the active pharmaceutical ingredient (API), perform various functions that enhance the effectiveness, stability, and overall performance of drug products. Understanding the common types of excipients is essential for pharmaceutical scientists and formulators, as it aids in the development of effective ...
As seasonal allergies affect millions globally, the demand for advanced, reliable treatments is growing rapidly. Behind the scenes of this progress lies a powerful class of materials: fluoropolymers. While often associated with aerospace, semiconductor, and chemical industries, fluoropolymers also play a vital—yet underappreciated—role in pharmaceutical manufacturing, particularly in ...
Among the various production systems available, Chinese Hamster Ovary (CHO) cells have emerged as a gold standard for monoclonal antibody production, and specialized services have been developed to streamline this process. ...
In our last blog, Peter discussed how AI is accelerating the drug discovery process and putting pressure on chemists, who must find ways of developing these potential drugs for subsequent testing or production. ...
ByBUCHI
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. ...
Antibody-Drug Conjugates (ADCs) represent a groundbreaking advancement in targeted cancer therapy, combining the specificity of antibodies with the potency of cytotoxic drugs. ...
It is used in dressings and other wound care products. l Drug Delivery: Researchers are exploring the use of bioglass as a drug delivery system. Its porous structure allows it to be loaded with drugs, which can then be released slowly over time as the bioglass degrades. ...
ByMatexcel
By determining the flux of these compounds, scientists can uncover how organisms regulate energy production, biosynthesis, and other critical cellular processes under various conditions. ...
Recombinant protein drugs refer to protein products that originate from animals and plants and are developed through biotechnology research. ...
Antibody drugs are a kind of drugs that treat diseases through artificially synthesized antibodies, achieving therapeutic purposes by specifically binding with target molecules. ...
Peptide drugs are bioactive protein fragments composed of short chains of amino acids. ...
Subsequently, Creative Bioarray provided three lots of each GMP cytokine for performance equivalence and lot-to-lot consistency testing. Product transitions from research-use products to cGMP manufacturing are easiest if GMP is available from the same supplier that provides the research-use-only (RUO) protein. ...
Applications of Bacterial Genome Editing The realm of bacterial genome editing is teeming with potential biotechnological applications, as diverse as drug discovery, disease modeling, biofuel production, and more. For instance, bacterial genome editing systems are being explored in the modification of gut microbiota. ...
Antibody drugs, as a breakthrough in biotechnology, are now widely used in the treatment of various diseases, including cancer, autoimmune diseases, and infectious diseases. ...
HCP (Host Cell Proteins) residual detection is a key quality control step in the field of biopharmaceuticals, aiming at ensuring that the proteins of the host cells used for producing therapeutic proteins in any cell-based production system are maintained at acceptable low levels in the final drug product.ImportanceHCPs are impurities during the ...
Introduction The pharmaceutical industry faces stringent regulatory requirements to ensure the safety, efficacy, and quality of drug products. Among these, Current Good Manufacturing Practice (CGMP) guidelines set by agencies such as the U.S. Food and Drug Administration (FDA) play a pivotal role. Pharmaceutical CGMP manufacturing encompasses all ...
Under the combination of sequencing and structural biology, the conformation of the protein is also revealed, providing valuable information for drug design and interaction research.2. Peptide MimeticsPeptide sequencing can accurately determine the sequence of peptides, which helps to design peptide drugs that mimic natural protein interactions, providing strong ...
Compared with protein drugs, peptide drugs also have advantages such as good stability, high purity, low production cost, and low immunogenicity. ...
Antibody drugs, particularly monoclonal antibodies (mAb), play a critical role in the treatment of many diseases, especially in the treatment of cancer and immunological disorders. To ensure the effectiveness and safety of these antibody drugs, it is necessary to perform activity testing.Definition of Antibody ActivityThe activity of an antibody ...
These specially sized polymers are designed to improve the stability and delivery of proteins and peptides in drugs. They are essential for Antibody-Drug Conjugate (ADC) linkers, Proteolysis Targeting Chimeras (PROTAC) linkers, and PEGylated proteins and peptides. ...