Drug Safety Evaluation Articles & Analysis
33 articles found
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes. To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freely ...
The MDCK permeability assay is a critical technique employed in pharmacology and drug development to evaluate the permeability of drug candidates across epithelial cell layers. This assay utilizes Madin-Darby Canine Kidney (MDCK) cells, which are a widely used model for studying intestinal absorption and permeability due to their similarity to human epithelial cells. Importance of the MDCK ...
Histological image analysis has emerged as a pivotal domain in biomedical research and clinical diagnostics, allowing scientists and healthcare professionals to decipher the intricate structures of tissues at a microscopic level. This analysis encompasses the examination of biological tissues to understand their composition, organization, and pathology, which can be crucial for diagnosing ...
In recent years, the rise of drug-resistant cells has emerged as one of the most significant challenges in the field of medicine, particularly in oncology and infectious diseases. The effectiveness of current therapies is often hindered by the ability of certain cell populations to develop resistance, leading to treatment failure and disease progression. This article explores the importance of ...
The evolution of 3D printing technology has opened up new avenues in the pharmaceutical industry, especially in the fabrication of novel drug delivery systems. One such advancement is the 3D printing of Oral Thin Films (OTFs), which are ultra-thin films used to deliver drugs via oral mucosa. Unlike traditional methods, 3D printing allows the precise layering of active pharmaceutical ingredients ...
Pharmaceutical Development: These cell lines are essential in the drug discovery pipeline, allowing for high-throughput screening and functional assays to evaluate drug efficacy and safety. ...
The world of drug development has long been marked by the rigorous assessment of cardiac safety. ...
Antibody drugs are a type of drugs that treat diseases through artificially synthesized antibodies, which bind specifically to target molecules for therapeutic purposes. Common types of antibody drugs include monoclonal antibodies, artificially synthesized antibody fragments, immunotoxins, and antibody-drug conjugates, etc. Antibody drugs have shown significant therapeutic effects in the ...
Recombinant protein drugs are protein-based therapeutic drugs which are produced by using DNA recombination technology or other biotechnological methods. These drugs include cytokines, peptide hormones, recombinant enzymes, monoclonal antibodies, and fusion proteins. Compared to traditional low-molecular-weight synthetic drugs, recombinant protein drugs have advantages such as high specificity, ...
Sialic acid proteins are a special type of glycoproteins, characterized by the presence of sialic acid at the end of the sugar chain. Sialic acid is a biologically important sugar molecule that plays a crucial role in many intercellular interactions, including cell recognition, adhesion and signal transduction. Therefore, the detection of sialic acid proteins holds significant value in disease ...
The scientific realm behind the development and evaluation of therapeutic drugs, pesticides, industrial and environmental chemicals profoundly relies on a field of research called Pharmacokinetic/Toxicokinetic (PK/TK) studies. ...
When we look at the awe-inspiring architecture of life at the cellular level, one of the most intriguing and essential features is the cytoskeleton. This dynamic network of protein filaments provides structure, facilitates movement, and enables intracellular transport. Advances in technology have revolutionized our understanding of the cytoskeleton and have expanded the possibilities of ...
This not only helps ensure therapeutic effects but also reduces non-specific damage to healthy cells.2. Evaluate Drug Release MechanismsAfter reaching the cancer cells, ADC needs to release the drug components into the cancer cells through an effective release mechanism. ...
Peptide drugs are bioactive molecules formed by connecting multiple amino acids through peptide bonds. Generally, they are formed by connecting 10-100 amino acids, with a relative molecular mass lower than 10000. Most peptide drugs come from endogenous peptides or natural peptides, so they have no or little side effects on the human body. Compared to protein drugs, peptide drugs also have ...
In addition, ADCs prepared by the current production process usually contain non-ADC forms, including naked antibodies and free small molecule drugs. When the ADC molecule enters the body, the conjugated drug is released from the ADC over time during the circulation process, resulting in a change in DAR, and its effectiveness and safety may also ...
MtoZ Biolabs, leveraging high-precision mass spectrometry technology in conjunction with a chemical proteomics platform, provides you with high quality Collagen Analysis services and other Medical Device services. As a leading biotechnology company, MtoZ Biolabs is committed to providing comprehensive, one-stop CRO testing services to scientific research institutions and pharmaceutical companies ...
If a stroke occurs, brain cells will be damaged or even die within a short period of time, resulting in damage to the brain and the body will not be able to work properly. Screening and evaluation of safe and effective anti-stroke drugs can help in the treatment and prevention of the disease. Approaches to the Evaluation of Anti-stroke ...
Application of flow cytometry in drug development and research FC has a wide range of applications and participates in all aspects of the entire drug development process, including drug development and target confirmation, non-clinical safety and toxicity evaluation, and clinical research. 1. ...
CD Genomics, a well-established leader in transcriptome solutions, is pleased to announce the introduction of Ribosome Profiling technology. This innovative technique promises to provide valuable insights into gene expression, protein synthesis, and regulation, offering potential advancements in the field of RNA translation research. Ribo-seq is a cutting-edge high-resolution sequencing ...
Microencapsulation technology has revolutionized drug delivery systems, allowing for the protection and controlled release of therapeutic agents. Microcapsules, tiny spherical structures capable of encapsulating drugs, offer numerous advantages in terms of stability, targeted delivery, and improved patient outcomes. In this article, we will delve into the methods involved in preparing drug ...