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Element 7 Analysis Articles & Analysis
13 articles found
Abstract In pharmaceutical synthesis, heavy metal catalysts are commonly used, and their residues often remain in the final product. These heavy metals—primarily from catalyst residues—not only affect drug efficacy but also pose serious health risks to patients. As a result, pharmacopoeias in various countries impose strict limits on heavy metal content in pharmaceutical substances. ...
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs have been approved worldwide, of which the FDA has approved 13 ADCs for various cancers, including Adcetris®, Kadcyla®, Besponsa®, Mylotarg®, Lumoxiti®, Polivy®, Padcev®, Enhertu ®, Trodelvy® and Blenrep®. As ...
CD Genomics, a well-established leader in transcriptome solutions, is pleased to announce the introduction of Ribosome Profiling technology. This innovative technique promises to provide valuable insights into gene expression, protein synthesis, and regulation, offering potential advancements in the field of RNA translation research. Ribo-seq is a cutting-edge high-resolution sequencing ...
Nucleus replacement technologies are a minimally invasive alternative to spinal fusion and total disc replacement that have the potential to reduce pain and restore motion for patients with degenerative disc disease. Finite element modeling can be used to determine the biomechanics associated with nucleus replacement technologies. The current study focuses on a new nucleus replacement device ...
Abstract Transplantation of pancreatic islets has been shown to be effective, in some patients, for the long-term treatment of type 1 diabetes. However, transplantation of islets into either the portal vein or the subcutaneous space can be limited by insufficient oxygen transfer, leading to islet loss. Furthermore, oxygen diffusion limitations can be magnified when islet numbers are increased ...
Antibody-drug conjugate (ADC), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic agent into the tumor, has made significant progress in the previous decade. The first ADC drug approved by the US FDA was gemtuzumab ozogamicin (Mylotarg) in 2009. Currently, the FDA has authorized ...
Prediction of the first-in-human dosing regimens is a critical step in drug development and requires accurate quantitation of drug distribution. Traditional in vivo studies used to characterize clinical candidate’s volume of distribution are error-prone, time and cost intensive and lack reproducibility in clinical settings. The paper demonstrates how a computational platform integrating ...
A novel intervertebral disc nucleus replacement device is comprised of an elas-c silicone membrane filled with liquid in situ curable silicone to form an elastomeric implant surrounding a central gas chamber that allows inward deforma-on of the cured component under load. Samples of this device were subjected to finite element analysis (FEA), digital pressure mapping and biomechanical flexibility ...
An ideal bone grafting material should be compatible with physiological environment, provoke osseous tissue formation and adapt degradation behaviour to new bone tissue growth. Calcium phosphates, a main inorganic constituent of the human hard tissue, are by far the best substitute materials for bone reconstruction because of their excellent bioactivity, biocompatibility and osteoconductivity. In ...
The early fixation of pedicle screws is crucial for improving spinal stabilisation. Firm and immediate fixation between pedicle screws and bone prevents aseptic loosening and implant failure. Coating with hydroxyapatite is a possible method to improve the fixation of metallic implants in bone. In this study, scanning transmission electron microscopy (STEM) has been used to investigate the ...
The present study evaluated if the element profiles in hair and nails of children from the Lake Victoria region in Kenya reflect uptake from food and the environment. To this purpose, the element concentrations in hair and nails were related to element concentrations measured in food items, water, and soil. The highest intake of most elements occurred via ingestion of the fish Rastrineobola ...
Finally, we evaluated the specific interaction between the protoporphyrin and gold nanoparticles by the elemental analysis, atomic absorption and UV-vis spectrum. Transmission electron microscopic images reveal the spherical gold nanoparticles formation with the average size about 7 nm. ...
There is a lack of adequate and cost-effective treatment options for many neurodegenerative diseases. The number of affected patients is in the millions, and this number will only increase as the population ages. The developing areas of neuromimetics and stimulative implants provide hope for treatment, as evidenced by the currently available, but limited, implants. New technologies are emerging ...