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Gene Cell Therapy Articles & Analysis
76 articles found
Fluoropolymers: A Critical Enabler in Cell and Gene Therapies Cell and gene therapies are revolutionizing medicine, offering cures for rare diseases and innovative treatments for cancer. Behind every successful therapy is a precise and sterile manufacturing process—where ...
Future Directions in Research As science continues to unravel the complexities of neurotrophic factors, novel therapeutic approaches are being developed. Gene therapy techniques to deliver neurotrophic factors directly to affected regions of the brain, as well as the use of small molecules that can mimic their action, are areas of active research. ...
l Complex product formats: Bispecific antibodies, antibody-drug conjugates, and fusion proteins introduce unique purification challenges. l Gene and cell therapies: Large biomolecules like adeno-associated virus (AAV) or lentiviral vectors are difficult to purify at scale. ...
This approach allows for the insertion of genes encoding viral proteins into suitable expression systems such as bacteria, yeast, or mammalian cells. ...
Among various delivery systems, lentiviruses have garnered significant attention due to their ability to introduce genetic material into both dividing and non-dividing cells, making them an ideal vehicle for gene therapy applications. Understanding CRISPR/Cas9 Technology CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) coupled ...
Adenoviruses are a group of viruses that have gained significant attention in recent years, particularly in the fields of gene therapy, vaccine development, and cancer treatment. With their ability to deliver genetic material into cells effectively, adenoviruses serve as valuable vectors in various biomedical applications. ...
The BCL2 gene, short for B-cell lymphoma 2, is a critical regulator of apoptosis, or programmed cell death. It belongs to a larger BCL2 gene family, which includes both pro-apoptotic and anti-apoptotic proteins that maintain a delicate balance between cell survival and cell death. ...
Podocytes are specialized epithelial cells located in the kidneys, playing a crucial role in the filtration barrier of the glomerulus. These unique cells have garnered significant attention in scientific research due to their pivotal function in maintaining kidney health and their involvement in various kidney diseases. ...
By creating cell lines with specific genes “knocked out,” scientists can investigate disease mechanisms, screen drug candidates, and develop gene therapies more effectively. ...
This breakthrough could significantly enhance treatment options for high-risk patients. 3. Stem Cell-Derived Cardiac Muscle Patches A cutting-edge approach using stem cell-derived cardiac muscle patches has shown the potential to repair damaged heart tissue. ...
They play a critical role in RNA interference (RNAi), a biological process used by cells to regulate gene expression and defend against viral infections. ...
Human mesenchymal stem cells (hMSCs) are a remarkable type of stem cell found in various tissues, such as bone marrow, adipose tissue, and umbilical cord. ...
These technologies allow scientists to cut, insert, or modify specific DNA sequences, enabling the customization of T cells to recognize and attack disease-specific antigens. Applications in Cancer Therapy One of the most promising applications of gene editing in primary T cells is in cancer therapy. ...
In recent years, messenger RNA (mRNA) technology has emerged as a revolutionary approach in the field of medicine, particularly in vaccine development and gene therapy. The ability to deliver mRNA effectively to target cells is crucial for harnessing its potential in treating a variety of diseases, including infectious diseases, cancer, and ...
In recent years, adeno-associated virus (AAV) particles have emerged as a pivotal tool in the realm of gene therapy, offering researchers and clinicians innovative approaches to treat a variety of genetic disorders. ...
But the applications of mRNA extend far beyond vaccines: Cancer Treatment: Enzymes facilitate the development of mRNA-based therapies. Researchers work to create mRNA molecules that instruct the body’s immune system to produce proteins specific to tumor cells, thereby training the immune response to recognize and attack those cells more ...
This article aims to engage in an incisive analysis of cell and gene therapies, decoding their transformative implications on human health and medical research. ...
Scientists are using a variety of gene delivery strategies to insert new genes into cells. One common biological system is viral gene delivery, where the viral vectors are modified to carry the genes and deliver them to the target cells. The vectors have been used safely in gene ...
In recent years, the field of biotechnology has seen groundbreaking advancements, with the integration of artificial intelligence (AI) into gene editing and therapy. AI-driven technologies have transformed the way we approach genetic modification and treatment, offering unprecedented opportunities for precision medicine and therapeutic interventions. One of the most significant applications of ...
Applications: Functional Studies: Creating knockout models to study the roles of specific cytoskeletal components. Therapeutics: Developing gene therapies for diseases caused by cytoskeletal malfunctions (e.g., certain muscular dystrophies). ...