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Hematopoietic Cells Articles & Analysis
12 articles found
Cytokines are a broad class of tiny proteins that are essential for controlling inflammation and immunological responses. Numerous cell types, including fibroblasts, endothelial cells, immunological cells, and epithelial cells, produce these signaling molecules. Serving as intermediaries, they synchronize various cell functions to elicit the body's defense mechanisms against infections, tissue ...
What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. As a "living" drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted therapy for the treatment of tumors. Compared with ...
Autoimmune disease target - IL-17 Family IL-17 plays an important role in promoting autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis (AS). Currently, five large-molecule biopharmaceuticals targeting IL-17/IL-17R are available worldwide, including four IL-17 monoclonal antibodies and one IL-17RA monoclonal antibody, namely Secukinumab(Novartis), Ixekizumab(Eli ...
Chimeric antigen receptor T cells (CAR-T) and T cell antigen receptor chimeric T cells (TCR-T) are currently the "top stream" in adoptive T cell tumor immunotherapy. In particular, CAR-T therapy, which has been approved by the FDA, is rewriting the treatment paradigm of some hematological tumors. However, adoptive T cell therapy remains of little success in solid tumors. The main reason is that ...
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resource of enzymes with the ability to metabolize drugs. The diversity of gut bacteria also affects the mental health of the host. Microbiomes from ...
Fatty acids, along with glucose and amino acids, are the main source of energy for cell growth and proliferation. Abnormalities in fatty acid metabolism are commonly seen in cancer. A growing number of studies have shown that increased ab initio synthesis of fatty acids in tumor cells is a prominent feature in the development of cancer. And the activation of ab initio synthesis is negatively ...
At an academic conference on Feb 15, U.S. experts announced the world's first female AIDS "cure," making it the third case of HIV infection to be cured. After therapy and withdrawal of antiviral drugs, HIVs were not identified in the patient's body for more than 14 months, indicating that the virus was in complete remission, according to academics. The key to this patient's recovery was a blood ...
Cytokines are a class of small molecule proteins secreted by cells that mediate and regulate immune processes, and they act in an autocrine, paracrine and endocrine manner. More than 200 types of human cytokines have been identified, which can be generally classified into interleukins, interferons, tumor necrosis factors, colony-stimulating factors, chemokines, growth factors, etc. according to ...
The maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls the response to acute microbial infection through the involvement of STAT1 transcription factors. However, the contribution of tonic levels of interferon to immune homeostasis in the absence of acute infection remains largely unexplored. The ...
Q. Tell us about your role as a Research Scientist and Project Lead at Regeneus? A. My role is extremely diverse and has evolved over my time at Regeneus. Initially, I was responsible for optimising our product manufacturing processes, including manufacturing products for our preclinical and clinical trials. For example, I provided the data to support preclinical studies that evaluated ...
Intraembryonic hematopoiesis occurs at two different sites, the floor of the aorta and subaortic patches (SAPs) of the para-aortic splanchnopleura (P-Sp)/aorta-gonad-mesonephros (AGM) region. Notch1 and RBP-j are critical for the specification of hematopoietic stem cells (HSCs) in Notch signal-receiving cells. However, the mechanism by which Notch signaling is triggered from the Notch ...
The PicTar program predicted that microRNA-126 (miR-126), miR-145, and let-7s target highly conserved sites within the Hoxa9 homeobox. There are increased nucleotide constraints in the three microRNA seed sites among Hoxa9 genes beyond that required to maintain protein identity, suggesting additional functional conservation. In preliminary experiments, forced expression of these microRNAs in ...