Heparins Articles & Analysis
12 articles found
What is Hydrogel? Hydrogels are a class of widely studied and applied biomaterials. Hydrogels have been widely studied as cell scaffolds and drug delivery vehicles because their chemical and physical properties are very close to the natural environment of cells. Hydrogels can encapsulate both cells and biomolecules, and many gel systems can closely control the release properties through ...
Feline herpesvirus type 1 (FHV-1) can cause acute and highly contagious infectious diseases in cats, namely feline infectious rhinotracheitis. In 1958, FHV-1 was isolated and identified for the first time from kittens suffering from respiratory diseases in the United States by Crandell et al. Clinical manifestations include keratoconjunctivitis, upper respiratory tract infection and miscarriage, ...
Lipoprotein lipase (LPL) is a glycoprotein synthesized and secreted by parenchymal cells such as adipocytes, cardiomyocytes, skeletal muscle cells, mammary cells, and macrophages, with a molecular weight of 60ku and containing 3-8% carbohydrates. The physiological function of LPL is to catalyze the breakdown of TG in the core of CM and VLDL into fatty acids and monoglycerides for tissue oxidative ...
Heparin, also known as standard heparin or unfractionated heparin, is a linear polysaccharide consisting of 1-4 linked disaccharide repeat units of uronic acid and glucosamine residues. Heparin was discovered nearly 100 years ago and has been used clinically as a blood anticoagulant since 1935. This is due to its ability to bind to the antithrombin(serine protease inhibitor), causing the ...
What do rat poison and anticoagulation medicine have in common? As often happens in scientific discovery, research follows a twisted route to the most effective remedy. ...
Discovery In the late 19th century, researchers attempted to produce a drug with a hemostatic effect by injecting a peptone and inducing the release of an anticoagulant. The water-soluble substance isolated from the liver was heparin, but no one knew it at the time. What unfolded over the next four decades would change the trajectory of anticoagulation treatment. By 1915, the most prominent ...
Glycosaminoglycan (GAG) is a general term for the glycan part of proteoglycan macromolecules. Glycosaminoglycans are large linear polysaccharides composed of repeating disaccharide units, and their main configuration contains amino sugars and uronic acids (glucuronic acid and/or iduronic acid). Glycosaminoglycans can be divided into chondroitin sulfate, dermatan sulfate, keratan sulfate, ...
Sugar is an important nutrient for the human body, and its primary physiological function is to provide energy and carbon sources for life activities. In addition, sugar also participates in the composition of glycoproteins and glycolipids, and regulates cell information transmission. Monosaccharides are polymerized by glycosidic bonds to form oligosaccharides or polysaccharides, also called ...
In-vivo Evaluation Of A Novel Surgical Heart Valve Prosthesis Designed To Be Durable, Anticoagulant-free And Silent. Bart Meuris, Lucas Van Hoof, Wilm Decré, Marie Lamberigts, Tom Langenaeken, Peter Verbrugghe. KU Leuven, Leuven, Belgium. OBJECTIVE: Heart valves prostheses still face limitations: reoperations with tissue valves or lifelong anticoagulation with mechanical valves. The ...
Today, HIT remains a critical clinical context in many hospital settings, when heparin, mainly unfractionated, is used in cardiology, intensive care units, or ECC, including CPB and increasingly ECMO. This is a paradoxal disease, as this anticoagulant drug can provoke thrombocytopenia associated with thrombosis in affected patients. Detecting the risk of HIT is mandatory, as it requires an ...
Immunoassays for heparin dependent antibodies have been introduced since the discovery of PF4 as the major target antigen in presence of heparin. Different immunoassay presentations are available, and interestingly heparin can be replaced by polyanions complexes and its native structure is then altered as shown on figure 3. This alteration exposes PF4 epitopes, characteristic of the ...
Many of the heparin dependent antibodies, including those with the IgG isotype, are asymptomatic, and only a subgroup of antibodies is positive in platelet activation assays. What differentiates pathogenic from asymptomatic antibodies is not fully understood, with the exception that there is some relationship between antibody concentration and occurrence of HIT, and that antibodies with the ...