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Hplc Analysis Articles & Analysis

5 articles found

ADC Development and Production: Innovations and Best Practices

ADC Development and Production: Innovations and Best Practices

Antibody-Drug Conjugates (ADCs) represent a groundbreaking advancement in targeted cancer therapy, combining the specificity of antibodies with the potency of cytotoxic drugs. The development and production of ADCs are complex processes that require a deep understanding of both biology and chemistry, alongside cutting-edge technology. This article delves into the intricacies of ADC development ...

ByCreative Biogene


Determination of Monosaccharide Content and Types in Recombinant Protein Vaccines

Determination of Monosaccharide Content and Types in Recombinant Protein Vaccines

During the production process, the content and type of monosaccharides may be affected by many factors, such as the type of host cell, culture conditions, protein folding, and glycan assembly, etc. Therefore, detailed analysis and control of the monosaccharide content and types in recombinant protein vaccines are very important.To analyze the content and types of monosaccharides ...

ByMtoZ Biolabs


An in vitro method for determining the bioaccessibility of pharmaceuticals in wildlife

An in vitro method for determining the bioaccessibility of pharmaceuticals in wildlife

Samples of gizzard (or stomach) and intestinal phase digestive juices were obtained from the in vitro models along with the residual solid material. HPLC analysis revealed that the bioaccessibility of fluoxetine in the avian in vitro models (75.9% and 78.6%) was statistically significantly lower than in the mammalian models (88.2‐89.6%) as a percentage of what ...

ByJohn Wiley & Sons, Ltd.


Enhanced degradation of paracetamol by UV-C supported photo-Fenton process over Fenton oxidation

Enhanced degradation of paracetamol by UV-C supported photo-Fenton process over Fenton oxidation

At the optimum conditions, for 20 mg/L of initial paracetamol concentration, 82% paracetamol reduction and 68% COD removal by Fenton oxidation, and 91% paracetamol reduction and 82% COD removal by UV-C Fenton process are observed in a 120 min reaction time. By HPLC analysis, 100% removal of paracetamol is observed at the above optimum conditions for the Fenton ...

ByIWA Publishing


An overview of post-column derivatization methods from a pharmaceutical applications perspective

An overview of post-column derivatization methods from a pharmaceutical applications perspective

High performance liquid chromatography (HPLC) is the technique of choice for separating analytes pursuant to their detection, identification, quantification and/or purification. Most organic substances, and certainly the majority of pharmaceuticals, are polar, nonvolatile or thermally labile molecules that are amenable to HPLC separation. Moreover, the availability of a large variety of LC column ...

ByPickering Laboratories, Inc.

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