Human Based Serum Articles & Analysis
8 articles found
Therefore, nanobodies are preferred tracers with wide applications in the field of molecular diagnostics.Non-invasive molecular diagnostics based on nanobodies are in the development stage. Studies have reported that EGFR nanobodies labeled with radioactive element 99mTc can accurately detect EGFR-positive tumor cells. ...
These linkers can be divided into cleavable linker and non-cleavable linker. ADCs based on non-cleavable linkers must be internalized and the antibody needs to be degraded by lysosomal proteases to release active molecules. ...
Antibody-drug conjugates (ADCs), as emerging anticancer drugs, can deliver highly cytotoxic molecules directly to cancer cells to kill them. ADC is a monoclonal antibody covalently bound to cytotoxic chemical substances (payload) through linker. ADC linker plays a key role in the therapeutic effect of ADC, and its characteristics greatly affect the therapeutic index, pharmacodynamics and ...
Glucose oxidase (GOD) is a typical oxidoreductase found in honey and molds such as Penicillium notatum. It can highly specifically catalyze the β-D-glucose reaction to generate gluconic acid, which has the function of converting glucose and removing oxygen. Since GOD can quantitatively generate hydrogen peroxide, it is widely used in the field of biochemistry and clinical examination as a ...
The study of both serum antibodies and antibodies encoded by memory B cells in donors with recent AAV exposures can reveal key characteristics of human anti-capsid antibody responses and provide a more complete picture of anti-capsid antibody immunity. ...
This paper describes the effects of prolonged antioxidant therapy, its stability and association with spectral parameters of the fluorescent probe ABM in blood plasma and indices of albumin auto-fluorescence in Chernobyl clean-up workers from Latvia. Patients were divided into two groups. Group 1 received placebos of identical appearance to antioxidants. Group 2 received antioxidants (vitamin E + ...
The aim of this paper is to present a method for the labelling human albumin nanospheres with the short lived beta emitter 188Re. In this method stannous chloride is used as reducing agent and potassium sodium tartrate as transchelation agent. Optimal parameters of the labelling reaction and also, the stability of the radiolabelled nanospheres were established. Under optimal reaction condition, ...
Regional administration of labelled particles by intra-arterial infusion is an effective method for endoradiotherapy of tumours. The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter 188Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was ...