Human Serum Albumin Articles & Analysis
8 articles found
The clinical research targets of nanobodies used for molecular diagnosis include HER2, HER3, PD-L1, AlbudAb, CD20, CD38, CD8, CEA and HGF, etc., mainly involving the field of tumor targeted diagnosis.Nanobodies for Disease TreatmentCamelid IgG antibodies are highly homologous to human IgG, and their immunogenicity can be reduced through nanobody humanization ...
Chemical-dependent linker The linker with disulfide bond is nucleophilic attacked by thiols to release the active payload. Although the reduction form of human serum albumin (HSA) in plasma is the most abundant thiol, it has poor reactivity to macromolecules. ...
Although ester bonds are theoretically more stable than carbonates in blood circulation, experimental results show that ADCs constructed from the former are less stable in human serum. The serum stability of the ADC was significantly improved (t1/2=36 hrs) by introducing a p-aminobenzyl (PABC) spacer, which showed some selectivity for the acidic ...
Project: Commercial Albumin Production Plant Capacity Expansion Client: Albumedix Limited Main Contractor: Scitech UK Duration: May 2019 – November 2020 Puretech designed, manufactured, installed and commissioned a fully validated system for the generation and distribution of essential pyrogen free water to replace the existing legacy system at Albumedix’s facility in ...
Publication Summary: Conventional cell therapy and tissue engineering approaches to treating liver diseases and injury are limited by low cell retention, poor engraftment, poor graft durability and complications including portal hypertension. Integration of next generation technologies such as 3D bioprinting is an essential step towards the clinical success of these promising approaches and has ...
This paper describes the effects of prolonged antioxidant therapy, its stability and association with spectral parameters of the fluorescent probe ABM in blood plasma and indices of albumin auto-fluorescence in Chernobyl clean-up workers from Latvia. Patients were divided into two groups. ...
The aim of this paper is to present a method for the labelling human albumin nanospheres with the short lived beta emitter 188Re. In this method stannous chloride is used as reducing agent and potassium sodium tartrate as transchelation agent. Optimal parameters of the labelling reaction and also, the stability of the radiolabelled nanospheres were established. Under optimal reaction condition, ...
The goal of the study was to develop an efficient method for radiolabelling of biodegradable human serum albumin microspheres with the beta emitter 188Re. The influence of different factors, as the reagents concentration, temperature, time, etc., on reaction yield was studied. ...