Immune Efficacy Articles & Analysis
8 articles found
Several technological improvements have contributed to the growth of enzyme therapeutics in rare disease research: l improved recombinant expression systems for large-scale enzyme production l enhanced purification and quality control processes l glycoengineering strategies that improve cellular uptake of therapeutic enzymes These developments have helped increase the stability, ...
Encapsulating anticancer drugs within its lipid bilayer improves drug accumulation in target tissues while reducing toxicity to healthy cells.Immunomodulatory TherapyFunctionalized DSPE-PEG-Mannose nanoparticles can modulate immune responses by interacting with mannose receptors on immune cells, contributing to novel treatments for immune-related ...
Poor water solubility can limit the bioavailability and therapeutic efficacy of many drugs. PEG derivatives, with their hydrophilic nature, enhance the solubility and stability of hydrophobic drugs. ...
In BALB/c mice, the transfection efficacy of frozen LUS-LNPs stored at −20°C for 12 months did not decrease and produced strong luciferase expression when compared with the fresh LNPs. ...
Peptide vaccines are increasingly seen as an economically efficient and safe approach to circumvent this issue.Peptide Vaccine DevelopmentThe vaccine development process is a challenging multi-step process: Antigen selection→Epitope selection→Adjuvant selection→Peptide vaccine synthesis→Immunization study→In vitro evaluation→Clinical trial.The development of peptide vaccines ...
About FluGen: FluGen, Inc. is a clinical-stage vaccine company transforming vaccine efficacy in respiratory diseases. The company’s lead candidate is M2SR, a supra-seasonal, live, single-replication, intranasal flu vaccine. Unlike standard of care flu vaccines, M2SR stimulates mucosal, humoral, and cellular immunity. In an unprecedented challenge trial, ...
Attenuated vaccines have become one of the important development directions due to their potential advantages in terms of immune effects, for example, attenuated influenza vaccines can be inoculated by intranasal spray that is simpler, economical, painless, and consistent with the natural route of infection; they can retain the natural structure of all or most antigens of the ...
Viruses are sometimes challenging to manufacture at scale, however, and can elicit immune responses that undermine efficacy or produce adverse events. Lipid nanoparticles provide a non-viral alternative, and several studies published over the past few years highlight the potential to tune their specificity. ...