Immune Mediated Disease Articles & Analysis
2 articles found
Introduction to HLA Human leukocyte antigen (HLA) is a 3.6 Mb segment on the short arm of chromosome 6 that contains over 200 genes. It is also known as the major histocompatibility complex (MHC), and it is the most polymorphic region in the human genome, involving diverse immune reactions. HLA is divided into HLA-class I (corresponding to MHC class I) and HLA-class II (corresponding to MHC class ...
The rise in recent decades of diseases such as inflammatory bowel disease and rheumatoid arthritis suggests that factors in the environment are contributing. In 1932, New York gastroenterologist Burrill Crohn described an unusual disease in 14 adults. The patients had bouts of abdominal pain, bloody diarrhea, and lesions and scars on the bowel wall. Doctors in other parts of North America and ...
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