Immune Modulation Articles & Analysis
20 articles found
Watertown, MA – March 24, 2025 – Biopharma PEG, a leading supplier of high-quality polyethylene glycol (PEG) derivatives, highlights its innovative product DSPE-PEG-Mannose, an advanced biomedical polymer with significant potential in drug delivery, tumor-targeted therapy, tissue recognition, and adhesion.Structural Advantages of DSPE-PEG-MannoseDSPE-PEG-Mannose is composed of three key ...
Immunotoxicology is a specialized field that focuses on the assessment of how chemical substances affect the immune system. With the advancement of pharmaceuticals, environmental pollutants, and industrial chemicals, the need for comprehensive immunotoxicological evaluations has become paramount. This article explores the significance of immunotoxicology services, their methodologies, and their ...
Cytokines and growth factors are essential signaling molecules that play pivotal roles in immune regulation, inflammation, tissue repair, and numerous physiological and pathological processes. To comprehensively study these molecules, scientists often rely on high-throughput and sensitive technologies, among which Luminex Cytokine Panels have become a gold standard. This article delves into the ...
In recent years, messenger RNA (mRNA) technology has emerged as a revolutionary approach in the field of medicine, particularly in vaccine development and gene therapy. The ability to deliver mRNA effectively to target cells is crucial for harnessing its potential in treating a variety of diseases, including infectious diseases, cancer, and genetic disorders. This article explores the latest ...
The immune system plays a crucial role in protecting the body from harmful pathogens and foreign invaders. Immune receptors, which are protein molecules expressed on the membrane of immune cells, play a key role in regulating immune responses. These receptors can interact with specific ligands to trigger a cascade of events that lead to the activation or suppression of immune responses. Immune ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, ...
Cancer is a complex disease that involves a delicate interplay between the tumor cells and the host immune system. Cytokines play a critical role in this interplay, mediating the communication between different cells of the immune system and modulating immune responses. As such, cytokine profiling is becoming increasingly important in the study of cancer and is being used to support research, ...
Summary Inflammation is a hallmark of the tumor microenvironment and an area of active investigation. To better understand how tumor inflammation differs from general inflammation, such as in gum disease, Drs. Prilic, Mair, and Erikson employed novel methods, which included high parameter flow cytometry and Ozette’s foundational technology–full annotation using ...
The World Health Organization in its report on Neglected Tropical Diseases has stated that there is overwhelming evidence to show that the burden caused by many of the 17 diseases that affect more than 1 billion people worldwide can be effectively controlled and, in many cases, eliminated or even eradicated. Leishmaniasis caused by Leishmania spp is one such example and poses a grave health risk ...
Cytokines are small soluble proteins that are secreted by immune cells and tissue cells to play a regulatory role between cells, including interferon (IFN), interleukin (IL), chemokines, colony-stimulating factors (CSF), tumor necrosis factors (TNF) and so on. Cytokines function in autocrine, paracrine or endocrine forms, and can regulate cell growth and differentiation, modulate immune response ...
RVx201 Herpes Vaccine Description 2022 RVx201 is a first-in-human herpes simplex virus type 2 (HSV-2) live-attenuated therapeutic vaccine modified to be interferon sensitive that destroys the ability of the virus to inhibit immune responses. Produced by Rational Vaccines, Inc., the technology is based on the pioneering research of the late Dr. William Halford, who dedicated over 25 years to ...
The advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy remains a major obstacle limiting its clinical application. The development of drug resistance is associated with multiple factors, including the level of PD-L1 expression in tumor cells, the tumor microenvironment, ...
The maintenance of immune homeostasis involves a synergistic relationship between the host and the microbiome. Canonical interferon (IFN) signaling controls the response to acute microbial infection through the involvement of STAT1 transcription factors. However, the contribution of tonic levels of interferon to immune homeostasis in the absence of acute infection remains largely unexplored. The ...
Q. How did you develop your interest in the regenerative medicine and stem cell space? A. Born and raised in Indonesia, where the curriculum was quite focused on science, I have always been intrigued in life sciences and everything related. I came to Australia for university in 2008 and completed a Bachelor of Biotechnology at the University of New South Wales (UNSW). While there was a myriad ...
A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, multiplexing and sequencing technologies have accelerated engineering of improved capsid properties such as production yield, packaging efficiency, ...
Abstract Gut microbiota play a major role in host physiology and immunity. Inflammatory bowel diseases (IBDs), the important immune-related diseases, can occur through immune system malfunction originating due to dysregulation of the gut microbiota. The aim of this study was to investigate the capabilities and mechanisms of Lactobacillus acidophilus (L. acidophilus) KBL402 and KBL409 treatment ...
I was fortunate to receive the SOT Supplemental Training for Education Program (STEP) award. With this award, I traveled to Sapienza Università di Roma in Italy, to the laboratory of Dr. Rita Businaro for what was intended to be a three-month training period focused on mesenchymal stem cells (MSCs), cells that modulate immune response and tissue repair. Dr. Businaro is an expert in MSCs ...
The enzyme-linked immunosorbent spot (ELISpot) assay is one of the most commonly used methods to measure antigen-specific T cells in both mice and humans. Some of the primary reasons for the popularity of the method are that ELISpot is highly quantitative, can measure a broad range of magnitudes of response and is capable of assessing critical cellular immune-related activities such as IFN-g ...
To address if the modulation of immunity balance by low dose radiation is involved in the enhancement of the anti-tumour function, we examined the effect of 0.5 Gy γ-irradiation on the Th1/Th2 immunity balance in Ehrlich Solid Tumour (EST)-bearing mice. Repeated 0.5 Gy γ-irradiation significantly delayed the growth of tumours. The cytotoxic activities of Natural Killer (NK) cells and Cytotoxic T ...
Although many Lactobacillus strains used as probiotics are believed to modulate host immune responses, the molecular natures of the components of such probiotic microorganisms directly involved in immune modulation process are largely unknown. We aimed to assess the function of polysaccharide moiety of the cell wall of Lactobacillus casei strain Shirota as a possible immune modulator which ...