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Impact Assessment Articles & Analysis: Older

18 articles found

Targeting RNA Splicing: Mechanisms and Strategies   

Targeting RNA Splicing: Mechanisms and Strategies  

RNA-Seq plays a crucial role in characterizing the splicing alterations, identifying specific targets, and assessing the impact of the interventions on splicing patterns. It provides a comprehensive and high-resolution view of the transcriptome, allowing researchers to investigate the effects of targeted approaches on RNA splicing. ...

ByCD Genomics


HUMAN HEALTH RISK ASSESSMENT (HHRA) NOTE NUMBER 3, DTSC-modified Screening Levels (DTSC-SLs)

HUMAN HEALTH RISK ASSESSMENT (HHRA) NOTE NUMBER 3, DTSC-modified Screening Levels (DTSC-SLs)

Here’s who might use this information and when: Environmental Consultants and Engineers: Professionals tasked with assessing the environmental impact of hazardous waste sites or permitted facilities. ...

ByESdat Environmental Data Software


What Is Metabolomics?

What Is Metabolomics?

This understanding can be crucial in elucidating the mechanisms of diseases and identifying novel therapeutic interventions. Assess Environmental Impact: Environmental metabolomics focuses on studying the effects of environmental factors, such as pollutants or toxins, on the metabolome. By identifying metabolic alterations induced by environmental stressors, ...

ByCreative Proteomics


Measuring impact in healthcare: how we know we are making a difference

Measuring impact in healthcare: how we know we are making a difference

To ensure that our products consistently meet and exceed expectations, we have instituted a comprehensive approach to assess their performance and impact in real-world scenarios. This approach involves a multifaceted strategy, starting with rigorous customer feedback mechanisms. ...

ByB Medical Systems


RNA Splicing and How to Target It

RNA Splicing and How to Target It

RNA-Seq plays a crucial role in characterizing the splicing alterations, identifying specific targets, and assessing the impact of the interventions on splicing patterns. It provides a comprehensive and high-resolution view of the transcriptome, allowing researchers to investigate the effects of targeted approaches on RNA splicing. ...

ByCD Genomics


Decreasing Benign Breast Ultrasound Biopsies: Prospective Use of AI Decision Support

Decreasing Benign Breast Ultrasound Biopsies: Prospective Use of AI Decision Support

One radiologist left the practice and four radiologists joined the practice in the assessed intervals. Impact on physician performance was assessed by comparing retrospectively obtained metrics of physician performance before Koios DS was in use to prospective metrics after Koios DS was implemented, following a 6-month acclimatization ...

ByKoios Medical, Inc.


A Combination of Ramucirumab Plus Pembrolizumab Lengthened Survival For Some Lung Cancer Patients

A Combination of Ramucirumab Plus Pembrolizumab Lengthened Survival For Some Lung Cancer Patients

"A phase 3 trial of this combination is warranted to better assess its impact." Huateng Pharma, as a leading pharmaceutical intermediates supplier in China, can provide CAS NO.137281-39-1, CAS NO.165049-28-5, CAS NO.1118-89-4, CAS NO.155405-80-4 and CAS NO.3140-73-6 from lab to commercial scale, which can be used as Pemetrexed disodium intermediates. ...

ByHunan Huateng Pharmaceutical Co. Ltd.


The Link Between Smoking and Cognitive Decline

The Link Between Smoking and Cognitive Decline

By now, you are likely aware of many of the well-established risks associated with smoking cigarettes, such as cancer, asthma, chronic obstructive pulmonary disease (COPD), diabetes, cardiovascular disease, and stroke. But did you know that research has discovered a link between smoking and cognitive decline? This research emphasizes the importance of identifying and controlling modifiable risk ...

ByAltoida, Inc.


Regenstrief, IU study finds assigning hospitalists by unit has both pros and cons

Regenstrief, IU study finds assigning hospitalists by unit has both pros and cons

Researchers from Regenstrief Institute and Indiana University School of Medicine have conducted the first time-motion study in more than a decade to assess the impact of geographic cohorting of hospitalists. Geographic cohorting –- restricting or localizing hospitalists and their patients to one or two inpatient units rather than having hospitalists travel ...

ByGlobal Hospital & Healthcare Management


EU Endocrine Disrupting criteria will have various implications for industry

EU Endocrine Disrupting criteria will have various implications for industry

In this article we examine the legal and political moves to regulate endocrine disruptors over the past 20 years and the most recent developments in this regard… There is growing concern in the EU and worldwide about the negative human health and environmental impacts possibly caused by endocrine disruptors. So, what are endocrine disruptors (ED)? ...

ByEnhesa - Global EHS & Product Compliance Assurance


High School Sports Concussions - Case Study

High School Sports Concussions - Case Study

Physical examination, including neurological examination was within normal limits. An ImPACT test (post-injury) assessment was completed. Lucy was noted to have a worsening score on several areas of the test as well as an increase in symptom score, including headache and confusion, after taking the test. ...

ByThe Medical Algorithms Company Limited


Prednisolone impairs embryonic and post‐hatching development and shell formation of the freshwater snail, Physa acuta

Prednisolone impairs embryonic and post‐hatching development and shell formation of the freshwater snail, Physa acuta

Premature embryonic hatching was observed in lower concentrations of 31.25 and 62.5 µg/L, whereas delayed hatching was seen in concentrations from 125 to 1000 µg/L. To assess impacts of PDS exposure on the hatched juveniles, the drug exposure was extended for another 28 d. ...

ByJohn Wiley & Sons, Ltd.


Dermal exposure of Eisenia andrei earthworms: Effects of heavy metals on metallothionein and phytochelatin synthase gene expressions in coelomocytes

Dermal exposure of Eisenia andrei earthworms: Effects of heavy metals on metallothionein and phytochelatin synthase gene expressions in coelomocytes

Parameters like total number of coelomocytes, riboflavin content in coelomocytes, expression of genes implied in metal homeostasis and detoxification mechanisms can be used as biomarkers in order to assess the impact of metals on Annelids. Defense biomarkers (detoxification gene expressions and coelomocyte parameters) were investigated in the ...

ByJohn Wiley & Sons, Ltd.


Impact of increased temperature on malaria transmission in Burundi

Impact of increased temperature on malaria transmission in Burundi

The focus in this paper is to assess whether the increase in (global) temperature would result in increase in malaria transmission in Burundi. ...

ByInderscience Publishers


Genomics-based drug innovation: visions and commercial viability

Genomics-based drug innovation: visions and commercial viability

In particular, we highlight and reflect critically on the disparity between the expectations and 'hype' surrounding genomics, and assess its impact, to date, on pharmaceutical innovation.Keywords: history of innovation, pharmaceuticals, financial markets, sociological approach, commercialisation, life sciences, genomics, drug innovation, biotechnology, ...

ByInderscience Publishers


Temperature and direct effects on population health in Brisbane, 1986–1995

Temperature and direct effects on population health in Brisbane, 1986–1995

To assess the impact of weather on human mortality, particularly among elderly people and people with diseases, the authors conducted an ecological study in Brisbane, Australia. Correlation and autoregressive integrated moving average (ARIMA) regression analyses assessed the relationship between weather and mortality in the general population and ...

ByNational Environmental Health Association (NEHA)


Commercialisation of bio-pharmaceutical therapies and risk management: the impact on the sustainability of markets for recombinant drugs

Commercialisation of bio-pharmaceutical therapies and risk management: the impact on the sustainability of markets for recombinant drugs

Based on a theoretical approach, which integrates the effects of learning and knowledge path dependencies into traditional neoclassical principal–agency theory, the impact of risk assessment procedures in four different countries (USA, UK, Germany, and Japan) on the emergence and sustainability of markets for (radical) new biotechnological knowledge is ...

ByInderscience Publishers


Development of biomarkers to detect the effects of organic pollution on aquatic invertebrates: recent molecular, genotoxic, cellular and immunological studies on the common mussel (Mytilus edulis L.) and other mytilids

Development of biomarkers to detect the effects of organic pollution on aquatic invertebrates: recent molecular, genotoxic, cellular and immunological studies on the common mussel (Mytilus edulis L.) and other mytilids

Recent years have seen the development of biological measurements (biomarkers) as tools for use in monitoring and environmental impact assessment, such biomarkers being indicative of contaminant exposure and/or impact. ...

ByInderscience Publishers

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