In Vitro Assessment Articles & Analysis
5 articles found
Abstract Cannabis is used by an estimated 192 million people around the world. Most people use cannabis through the inhalation of cannabis smoke, which contains combustion by-products that can negatively affect lung health. Knowledge of these risks has led to a growing interest in cannabis vaporizers, which heat the dry cannabis flower without burning. Vaporizing cannabis still releases ...
Flow cytometry (FC) is an important tool for analyzing complex pathways and responses of single cells, which can track cell phenotypes and functions in multiple dimensions. It is also increasingly applied in drug development. FC not only can detect intracellular and extracellular components, but also detect soluble analytes in serum or plasma samples, such as cytokines, drug complexes, or ...
To improve current bioaccumulation assessment methods, a methodology is developed, applied and investigated for measuring in vivo biotransformation rates of hydrophobic organic substances in the body (soma) and gastro‐intestinal tract of the fish. The method resembles the bioaccumulation OECD 305 dietary test but includes reference chemicals to determine both somatic and gastro‐intestinal ...
Bio‐equivalents (e.g., 17β‐estradiol or dioxin equivalents) are commonly employed to quantify the in vitro effects of complex human or environmental samples. However, there is no generally accepted data analysis strategy for estimating and reporting bio‐equivalents. Therefore, the aims of the present study are to 1) identify common mathematical models for the derivation of bio‐equivalents from ...
Studies concerning the impact of nanomaterials, especially fullerene (C60), in fresh water environments and their effects on the physiology of aquatic organisms are still scarce and conflicting. We aimed to assess in vitro effects of fullerene in brain and gill homogenates of carp Cyprinus carpio, evaluating redox parameters. A fullerene suspension was prepared by continued stirring under ...